Le Bouc Yves
Explorations fonctionnelles endocriniennes, Inserm, centre de recherche Saint-Antoine (UMRS 938), hôpital des Enfants Armand-Trousseau, hôpitaux universitaires Paris Est, AP-HP, Sorbonne universités, UPMC université Paris 06, Sorbonne universités, AP-HP, 75012 Paris, France.
Ann Endocrinol (Paris). 2017 Jun;78(2):83-87. doi: 10.1016/j.ando.2017.04.022. Epub 2017 Apr 28.
Pygmies are considered to be among the smallest humans. Their small size is an enigma that has puzzled numerous scientists. Many data have been collected concerning their clinical and biological phenotypes, genetics, lifestyle, culture and environment, but the reasons for their small size remain a matter of debate. Is it an adaptation to life in the tropical forest, an impact of the environment, an usual genetic feature or a mixture of these factors? Studies of the somatotropic axis have revealed that serum IGF-1 concentrations are low in this population, probably due to an impairment of the GH receptor. However, many uncertainties remain, and further hormonal, genetic and epigenetic studies will be required in the framework of multidisciplinary studies.
俾格米人被认为是身材最为矮小的人类群体之一。他们的矮小身材是一个令众多科学家感到困惑的谜团。关于他们的临床和生物学表型、遗传学、生活方式、文化及环境，已经收集了许多数据，但他们身材矮小的原因仍是一个有争议的问题。这是对热带森林生活的一种适应、环境的影响、一种常见的遗传特征，还是这些因素的综合作用？对生长激素轴的研究表明，该群体的血清胰岛素样生长因子-1（IGF-1）浓度较低，这可能是由于生长激素受体受损所致。然而，仍存在许多不确定性，在多学科研究框架内还需要进一步开展激素、遗传和表观遗传学研究。
