Cairns Rob A, Mak Tak W
The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 2C1.
The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada M5G 2C1.
Exp Cell Res. 2017 Jul 15;356(2):204-208. doi: 10.1016/j.yexcr.2017.04.029. Epub 2017 Apr 27.
Lorenz Poellinger was a leader in understanding the effects of altered microenvironmental conditions in tumor biology and in normal physiology. His work examining the effects of hypoxia and the HIF transcription factors has expanded our understanding of the role of the microenvironment in affecting the behaviour of both normal and malignant cells. Furthermore, his work provides a model for understanding the adaptive responses to other metabolic stress conditions. By investigating the molecular mechanisms responsible for the adaptive responses to metabolic stress in normal physiological situations, across pathological conditions, and in different model organisms, his work shows the power of combining data from different model systems and physiological contexts. In cancers, it has become clear that in order to evolve to become an aggressive malignant disease, tumor cells must acquire the capacity to tolerate a host of abnormal and stressful metabolic conditions. This metabolic stress can be thought of as a fire that tumor cells must douse with enough water to survive, and may offer opportunities to exploit smoldering vulnerabilities in order to eradicate malignant cells.
洛伦兹·珀林格是理解肿瘤生物学和正常生理学中微环境条件改变所产生影响的领军人物。他研究缺氧和低氧诱导因子转录因子作用的工作，拓展了我们对微环境在影响正常细胞和恶性细胞行为方面作用的理解。此外，他的工作为理解对其他代谢应激条件的适应性反应提供了一个模型。通过研究正常生理状态下、跨病理状况以及在不同模式生物中对代谢应激的适应性反应所涉及的分子机制，他的工作展示了整合来自不同模型系统和生理背景数据的力量。在癌症中，很明显，为了演变成侵袭性恶性疾病，肿瘤细胞必须获得耐受一系列异常和应激性代谢条件的能力。这种代谢应激可被视为一场火，肿瘤细胞必须用足够的水将其扑灭才能存活，并且这可能为利用潜在的弱点来根除恶性细胞提供机会。
