Lingabathula Harikiran, Yellu Narsimhareddy
Department of Pharmacology and Toxicology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, 506009, India.
Department of Pharmacology and Toxicology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, 506009, India.
Environ Toxicol Pharmacol. 2017 Jun;52:248-254. doi: 10.1016/j.etap.2017.04.015. Epub 2017 Apr 22.
The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase leakage, alkaline phosphatase, lipid peroxidation and total microprotein levels in BAL fluids after 1day, 1 week and 1 month post exposure periods. All the parameters were returned to normal values after 3 months post exposure period may be due to recovery. The rat lung histopathology displayed that accumulation of macrophages, inflammatory response and tissue thickening for both sizes of GNRs. 10nm GNRs increased all BAL fluid parameters significantly following 1day, 1 week and 1 month post exposure periods whereas 25nm GNRs have shown similar effects but less extent. These investigations proposed that the dose and size dependent pulmonary toxicity of GNRs.
本研究旨在通过支气管肺泡灌洗（BAL）液和肺组织病理学分析，评估经气管内滴注10纳米和25纳米金纳米棒（GNRs）后对大鼠的肺毒性。GNRs显示出在暴露后1天、1周和1个月时，BAL液中乳酸脱氢酶泄漏、碱性磷酸酶、脂质过氧化和总微蛋白水平升高，呈现剂量依赖性毒性。暴露后3个月，所有参数可能因恢复而恢复到正常水平。大鼠肺组织病理学显示，两种尺寸的GNRs均有巨噬细胞积聚、炎症反应和组织增厚。10纳米GNRs在暴露后1天、1周和1个月时显著增加了所有BAL液参数，而25纳米GNRs显示出类似的效果，但程度较小。这些研究表明GNRs具有剂量和尺寸依赖性的肺毒性。
