Ding Zenghui, Chen Yanyan, Wang Xi, Zhou Xu, Xu Yang, Ma Zuchang, Sun Yining, Jiang Ming
Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui, PR China; Department of Automation, University of Science and Technology of China, Hefei, Anhui, PR China.
Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui, PR China.
Drug Alcohol Depend. 2017 Jun 1;175:232-236. doi: 10.1016/j.drugalcdep.2017.02.010. Epub 2017 Apr 13.
Little is known about bone quality and its determinants in patients with opioid addiction. The goal of this study was to compare bone quality and its determinants in young opioid addicted women with a local group of young healthy women.
Using cross-sectional design, 104 women (mean age 29.9 yrs, range: 20-40 yrs, SD=7.8) with previous opioid addiction and current methadone substitution (3-30mg, daily) for 1-16 weeks were compared to 117 healthy women (mean age 31.0 yrs, range: 20-40 yrs, SD=5.9). Bone quality was examined with quantitative ultrasound. Anthropometric characteristics (body weight, fat free mass (FFM), fat mass) were obtained by bioelectrical impedance analysis. Substance use and other risk factors for low bone quality were assessed by questionnaire-based interviews.
More than one-quarter (34%) of patients had osteopenia (n=31) or osteoporosis (n=4), compared to 16% of the healthy control group having osteopenia (n=18). Bivariate correlation analysis demonstrated that age, body weight, and FFM correlated with bone quality (p<0.05) in healthy women, which were not found in patients. Multivariate analyses showed that in healthy controls, the determinants of bone quality were age, body height, physical activity, and BMI, but in patients, the determinant of bone quality was duration of drug intake.
Long-term opioid dependence in young women may lead to low bone quality. Efforts to increase awareness of low bone quality in young opioid addicted women should be considered so that effective treatment may be employed to lower future fracture risk.
对于阿片类药物成瘾患者的骨质量及其决定因素知之甚少。本研究的目的是比较年轻的阿片类药物成瘾女性与当地一组年轻健康女性的骨质量及其决定因素。
采用横断面设计，将104名曾有阿片类药物成瘾且目前正在接受美沙酮替代治疗（每日3 - 30毫克）1 - 16周的女性（平均年龄29.9岁，范围：20 - 40岁，标准差 = 7.8）与117名健康女性（平均年龄31.0岁，范围：20 - 40岁，标准差 = 5.9）进行比较。通过定量超声检查骨质量。通过生物电阻抗分析获得人体测量特征（体重、去脂体重（FFM）、脂肪量）。通过基于问卷的访谈评估物质使用情况和其他低骨质量风险因素。
超过四分之一（34%）的患者患有骨质减少（n = 31）或骨质疏松（n = 4），而健康对照组有16%的人患有骨质减少（n = 18）。双变量相关性分析表明，年龄、体重和去脂体重与健康女性的骨质量相关（p < 0.05），而在患者中未发现这种相关性。多变量分析表明，在健康对照组中，骨质量的决定因素是年龄、身高、身体活动和体重指数，但在患者中，骨质量的决定因素是药物摄入持续时间。
年轻女性长期阿片类药物依赖可能导致骨质量降低。应考虑提高对年轻阿片类药物成瘾女性低骨质量的认识，以便采用有效的治疗方法降低未来骨折风险。
