1例Ph1阳性慢性粒细胞白血病患者的细胞遗传学缓解

Cytogenetic remission in a Ph1-positive case of chronic myelogenous leukaemia.

作者信息

Zago M A, Costa F F, Bottura C

出版信息

Scand J Haematol. 1979 Jan;22(1):91-5. doi: 10.1111/j.1600-0609.1979.tb00407.x.

DOI:10.1111/j.1600-0609.1979.tb00407.x

Abstract

Unusual cytogenetic findings in a case of chronic myelogenous leukaemia in the course of an aplastic crisis induced by busulfan therapy are reported. The proportion of Ph1-positive cells in bone marrow aspirates fell from 100% before treatment to 8.6% following aplasia. It increased gradually during recovery, and normal cells still represented 25.7% of the metaphases 20 months later. After a 38-months' remission without therapy the disease relapsed and the Ph1 chromosome was found in 100% of the bone marrow cells.

摘要

报告了1例慢性粒细胞白血病患者在白消安治疗引起的再生障碍危象过程中的异常细胞遗传学发现。骨髓穿刺液中Ph1阳性细胞的比例从治疗前的100%降至再生障碍期后的8.6%。在恢复过程中逐渐增加，20个月后正常细胞仍占中期细胞的25.7%。在未经治疗的38个月缓解期后疾病复发，100%的骨髓细胞中发现了Ph1染色体。