慢性粒细胞白血病伴自发核型转换的25年生存期
Twenty-five year survival of chronic granulocytic leukaemia with spontaneous karyotype conversion.
作者信息
Singer C R, McDonald G A, Douglas A S
出版信息
Br J Haematol. 1984 Jun;57(2):309-13. doi: 10.1111/j.1365-2141.1984.tb02900.x.
Following busulphan-induced bone marrow hypoplasia a woman with chronic granulocytic leukaemia has survived 25 years from diagnosis. Since the last course of busulphan therapy in 1959 she has remained in clinical and haematological remission. Repeated cytogenetic analysis of bone marrow showed Philadelphia chromosome mosaicism with a minority of abnormal metaphases till 1969. Analysis of 150 metaphases in 1982 revealed no cells containing the Philadelphia chromosome. The possible significance of this spontaneous karyotype conversion is discussed.
一位慢性粒细胞白血病女性在接受白消安诱导的骨髓发育不全治疗后，自确诊以来已存活25年。自1959年最后一次白消安治疗疗程后，她一直处于临床和血液学缓解状态。对骨髓进行的反复细胞遗传学分析显示，直到1969年，费城染色体呈嵌合状态，只有少数异常中期细胞。1982年对150个中期细胞进行分析，未发现含有费城染色体的细胞。本文讨论了这种自发核型转换的可能意义。
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