Yamada Yuji, Abe Ryohei, Okano Yutaka, Miyakawa Yoshitaka
Department of Medicine, Kawasaki Municipal Kawasaki Hospital, Japan.
Department of Medicine, Mount Sinai Beth Israel, USA.
Intern Med. 2017;56(9):1085-1088. doi: 10.2169/internalmedicine.56.7862. Epub 2017 May 1.
We experienced a favorable outcome in an adult case of atypical hemolytic uremic syndrome (aHUS) after long-term eculizumab treatment. A 38-year-old Japanese man with a history of central retinal vein occlusion was admitted to our hospital with progressive dyspnea. He was found to have non-immune hemolytic anemia, thrombocytopenia, and acute renal failure two weeks after an episode of the common cold. Plasma exchange was ineffective; therefore, we initiated eculizumab after we excluded other thrombotic microangiopathies. Although long-term peritoneal dialysis was required, we successfully discontinued dialysis 18 months after the onset of aHUS with eculizumab.
在一例成年非典型溶血尿毒综合征（aHUS）患者接受长期依库珠单抗治疗后，我们获得了良好的治疗效果。一名38岁有视网膜中央静脉阻塞病史的日本男性因进行性呼吸困难入院。他在普通感冒发作两周后被发现患有非免疫性溶血性贫血、血小板减少症和急性肾衰竭。血浆置换无效；因此，在排除其他血栓性微血管病后，我们开始使用依库珠单抗治疗。尽管需要长期进行腹膜透析，但在aHUS发病18个月后，我们成功停用了依库珠单抗。
