Du Ying, Chen Baoan
Department of Hematology and Oncology (Key Department of Jiangsu Medicine), School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province, People's Republic of China.
Drug Des Devel Ther. 2017 Apr 18;11:1255-1261. doi: 10.2147/DDDT.S134529. eCollection 2017.
Leukemia is a clonal malignant hematopoietic stem cell disease. It is the sixth most lethal cancer and accounts for 4% of all cancers. The main form of treatment for leukemia is chemotherapy. While some cancer types with a higher incidence than leukemia, such as lung and gastric cancer, have shown a sharp decline in mortality rates in recent years, leukemia has not followed this trend. Drug resistance is often regarded as the main clinical obstacle to effective chemotherapy in patients diagnosed with leukemia. Many resistance mechanisms have now been identified, and multidrug resistance (MDR) is considered the most important and prevalent mechanism involved in the failure of chemotherapy in leukemia. In order to reverse MDR and improve leukemia prognosis, effective detection methods are needed to identify drug resistance genes at initial diagnosis. This article provides a comprehensive overview of published approaches for the detection of MDR in leukemia. Identification of relevant MDR genes and methods for early detection of these genes will be needed in order to treat leukemia more effectively.
白血病是一种克隆性恶性造血干细胞疾病。它是第六大致命癌症，占所有癌症的4%。白血病的主要治疗方式是化疗。虽然一些发病率高于白血病的癌症类型，如肺癌和胃癌，近年来死亡率已大幅下降，但白血病并未遵循这一趋势。耐药性通常被视为白血病患者有效化疗的主要临床障碍。目前已确定了许多耐药机制，多药耐药（MDR）被认为是白血病化疗失败中最重要和最普遍的机制。为了逆转MDR并改善白血病预后，需要有效的检测方法在初诊时识别耐药基因。本文全面概述了已发表的白血病MDR检测方法。为了更有效地治疗白血病，需要鉴定相关的MDR基因以及这些基因的早期检测方法。
