Huseynova Nigar, Çetinkaya Melisa, Baran Züleyha, Khalilov Rovshan, Mammadova Afat, Baran Yusuf
Department of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan.
Department of Natural Sciences, Western Caspian University, Baku, Azerbaijan.
Adv Exp Med Biol. 2025;1479:205-234. doi: 10.1007/5584_2024_828.
Flavonoids, a diverse group of natural compounds abundant in plants, fruits, and seeds, are not only responsible for the vibrant colors, fragrances, and flavors found in nature but also possess significant health benefits. Representing a secondary metabolite, these phytonutrients contribute to overall well-being. They have garnered considerable interest due to their diverse biological roles, encompassing antioxidant, anti-inflammatory, and anticancer properties. Flavonoids exert anticancer properties by interfering with different signaling pathways and molecules. Also, they have been demonstrated to exert chemosensitization features, where flavonoids may enhance the effectiveness of chemotherapy, and hold promise for improving cancer treatment outcomes as they have been discovered to make cancer cells more responsive to treatment. Understanding their influence on the regulation of cellular signaling provides a foundation for exploring their potential in combination with different chemotherapy agents and their possible single use for cancer treatment. Besides, they are believed to present a cost-effective approach to cancer therapeutics with possible implications for reducing the side effects of the current chemotherapy regimens, which can be a great therapeutic strategy for treating cancer types, including leukemia. This chapter explores potential approaches for creating anticancer treatments, focusing on leukemia, through integrating flavonoid nutraceuticals with traditional chemotherapy agents.
黄酮类化合物是一类存在于植物、水果和种子中的天然化合物，种类繁多。它们不仅赋予自然界鲜艳的颜色、芬芳的气味和独特的风味，还对健康有着显著益处。作为次生代谢产物，这些植物营养素对整体健康有益。由于其具有抗氧化、抗炎和抗癌等多种生物学作用，黄酮类化合物引起了人们的广泛关注。黄酮类化合物通过干扰不同的信号通路和分子发挥抗癌作用。此外，它们还具有化学增敏特性，即黄酮类化合物可能增强化疗效果，并且由于已发现它们能使癌细胞对治疗更敏感，因此有望改善癌症治疗效果。了解它们对细胞信号调节的影响，为探索它们与不同化疗药物联合使用的潜力以及它们可能单独用于癌症治疗奠定了基础。此外，人们认为它们为癌症治疗提供了一种经济有效的方法，可能有助于减少当前化疗方案的副作用，这对于治疗包括白血病在内的多种癌症类型可能是一种很好的治疗策略。本章探讨通过将黄酮类营养保健品与传统化疗药物相结合来开发抗癌治疗方法的潜在途径，重点关注白血病。
