Liu Jianjun, Chen Shangxiang, Geng Qirong, Liu Xuechao, Kong Pengfei, Zhan Youqing, Xu Dazhi
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.
Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center.
Onco Targets Ther. 2017 Apr 13;10:2155-2162. doi: 10.2147/OTT.S99282. eCollection 2017.
Several studies have highlighted the prognostic value of the albumin-globulin ratio (AGR) in various kinds of cancers. Our study was designed to assess whether AGR is associated with the prognosis of gastric cancer patients.
A total of 507 gastric cancer patients between 2005 and 2012 were included. The AGR was defined as the ratio of serum albumin to nonalbumin and calculated by the equation: albumin/(total protein - albumin). Furthermore, AGR was divided into two groups (low and high) using the X-tile software. Survival analysis stratified by AGR groups was performed.
The mean survival time for each group was 36.62 months (95% CI: 33.92-39.32) for the low AGR group and 48.95 months (95% CI: 41.93-55.96, =0.003) for the high AGR group. Patients in the high group (AGR ≥1.93) had a significantly lower 5-year mortality in comparison with the low group (AGR <1.93) (52.4% vs 78.5%, =0.003). The high AGR group showed obviously better overall survival than the low AGR group according to Kaplan-Meier curves (=0.003). Multivariate analysis showed that AGR was an independent predictive factor of prognosis in gastric patients.
Pretreatment AGR is a significant and independent predictive factor of prognosis.
多项研究强调了白蛋白球蛋白比值（AGR）在各类癌症中的预后价值。我们的研究旨在评估AGR是否与胃癌患者的预后相关。
纳入了2005年至2012年间的507例胃癌患者。AGR定义为血清白蛋白与非白蛋白的比值，通过以下公式计算：白蛋白/（总蛋白 - 白蛋白）。此外，使用X-tile软件将AGR分为两组（低和高）。对AGR分组进行生存分析。
低AGR组每组的平均生存时间为36.62个月（95%置信区间：33.92 - 39.32），高AGR组为48.95个月（95%置信区间：41.93 - 55.96，P = 0.003）。高AGR组（AGR≥1.93）患者的5年死亡率显著低于低AGR组（AGR < 1.93）（52.4%对78.5%，P = 0.003）。根据Kaplan-Meier曲线，高AGR组的总生存期明显优于低AGR组（P = 0.003）。多因素分析表明，AGR是胃癌患者预后的独立预测因素。
治疗前AGR是预后的重要独立预测因素。
