术前纤维蛋白原与前白蛋白比值及新型 FFC 评分对可切除胃癌患者的预后价值。
The prognostic value of preoperative fibrinogen-to-prealbumin ratio and a novel FFC score in patients with resectable gastric cancer.
机构信息
Department of Medical Oncology, Harbin Medical University Cancer Hospital, No. 150, Haping Road, Nangang District, Harbin, 150001, China.
Department of Radiology, Harbin Medical University Cancer Hospital, No. 150, Haping Road, Nangang District, Harbin, 150001, China.
出版信息
BMC Cancer. 2020 May 6;20(1):382. doi: 10.1186/s12885-020-06866-6.
BACKGROUND
Chronic inflammation is considered as a hallmark of gastric cancer (GC) and plays a critical role in GC progression and metastasis. This study aimed to explore the prognostic values of preoperative fibrinogen-to-prealbumin ratio (FPR), fibrinogen-to-albumin ratio (FAR), and novel FPR-FAR-CEA (FFC) score in patients with GC undergoing gastrectomy.
METHODS
A total of 273 patients with resectable GC were included in this retrospective study. We performed Kaplan-Meier and Cox regression analyses to assess the prognostic role of preoperative FPR, FAR, and FFC score in patients with GC and analyze their relationships with clinicopathological features.
RESULTS
Receiver operating characteristic curve (ROC) analysis revealed that the optimal cutoff values for FPR and FAR were 0.0145 and 0.0784, respectively. The FFC score had a higher area under the ROC curve than FAR and CEA. Elevated FPR (≥ 0.0145) and FAR (≥ 0.0784) were significantly associated with old age, large tumor size, tumor invasion depth, lymph nodes metastasis, advanced TNM stage, large Borrmann type, and anemia status. Kaplan-Meier analysis showed that high FPR, FAR, and FFC score were related to poor survival. Multivariate analyses indicated that FPR, FFC score, TNM stage, and tumor size were significant independent factors for survival.
CONCLUSIONS
Preoperative FPR and FFC score could be used as prospective noninvasive prognostic biomarkers for resectable GC.
背景
慢性炎症被认为是胃癌（GC）的一个标志，在 GC 的进展和转移中起着关键作用。本研究旨在探讨术前纤维蛋白原-白蛋白比值（FPR）、纤维蛋白原-白蛋白比值（FAR）和新型 FPR-FAR-CEA（FFC）评分在接受胃切除术的 GC 患者中的预后价值。
方法
本回顾性研究共纳入 273 例可切除 GC 患者。我们进行了 Kaplan-Meier 和 Cox 回归分析，以评估 GC 患者术前 FPR、FAR 和 FFC 评分的预后作用，并分析它们与临床病理特征的关系。
结果
受试者工作特征曲线（ROC）分析显示，FPR 和 FAR 的最佳截断值分别为 0.0145 和 0.0784。FFC 评分的 ROC 曲线下面积高于 FAR 和 CEA。升高的 FPR（≥0.0145）和 FAR（≥0.0784）与年龄较大、肿瘤较大、肿瘤侵袭深度、淋巴结转移、较晚的 TNM 分期、较大的 Borrmann 型和贫血状态显著相关。Kaplan-Meier 分析显示，高 FPR、FAR 和 FFC 评分与生存不良相关。多变量分析表明，FPR、FFC 评分、TNM 分期和肿瘤大小是生存的独立显著因素。
结论
术前 FPR 和 FFC 评分可作为可切除 GC 的潜在无创预后生物标志物。
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