Isik A, Okan I, Firat D, Yilmaz B, Akcakaya A, Sahin M
Department General Surgery Erzincan University Hospital, Erzincan Turkey -
Minerva Chir. 2014 Jun;69(3):147-53.
We evaluated the prognostic significance of preoperative serum albumin value and metastatic lymph node ratio for gastric cancer patients.
We studied patients diagnosed with gastric carcinoma in the first Department of Surgery, Bezmialem Vakif Gureba Training and Research Hospital between January 2004 and December 2010; the patients were studied retrospectively.
A total of 67 patients with a mean age of 58.7 ± 11.4 years were included in the study. The majority of patients were male (N.=53 male; N.=14 female). Most patients were in an advanced stage of the disease (stage III-IV) on admission (67.2%). We classified patients according to albumin value as "normal" Group 1 (83%) and "hypoalbuminemic" Group 2 (17%). With albumin, age, resection type, perineural invasion, and ratio of metastatic lymph nodes, T and TNM stages were significant predictors of cancer-specific survival.
As a result, irrespective of mechanism, pre-operative evaluations of albumin and metastatic lymph node ratio should be performed to stratify the patients for risk analysis and prognosis. A level less than 3.5 g/dL is a negative prognostic factor for resectable gastric cancers.
我们评估了术前血清白蛋白值和转移淋巴结比率对胃癌患者的预后意义。
我们研究了2004年1月至2010年12月在贝兹米阿勒姆瓦基夫古雷巴培训与研究医院第一外科被诊断为胃癌的患者；对这些患者进行回顾性研究。
共有67例患者纳入研究，平均年龄为58.7±11.4岁。大多数患者为男性（n = 53例男性；n = 14例女性）。大多数患者入院时处于疾病晚期（III - IV期）（67.2%）。我们根据白蛋白值将患者分为“正常”的第1组（83%）和“低白蛋白血症”的第2组（17%）。白蛋白、年龄、切除类型、神经周围侵犯以及转移淋巴结比率、T和TNM分期是癌症特异性生存的重要预测因素。
因此，无论机制如何，都应进行白蛋白和转移淋巴结比率的术前评估，以便对患者进行分层以进行风险分析和预后评估。低于3.5 g/dL的水平是可切除胃癌的不良预后因素。
