Serin Halil İbrahim, Yilmaz Yunus Keser, Turan Yaşar, Arslan Ergin, Erkoç Mustafa Fatih, Doğan Aytaç, Celikbilek Mehmet
Department of Radiology, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Department of Cardiovascular Surgery, Faculty of Medicine, Bozok University, Yozgat, Turkey.
J Res Med Sci. 2017 Jan 27;22:11. doi: 10.4103/1735-1995.199087. eCollection 2017.
The aim of this study was to assess the atheromatous plaque, in the abdominopelvic arteries as a marker of cardiac risk in patients with or without gallstone disease (GD).
A total of 136 patients were enrolled in this cross-sectional study. Forty-eight patients had GD and the remaining 88 patients did not. The presence or absence of gallstones was noted during abdominal ultrasonography while vascular risk factors such as plaque formation, intima-media thickness, plaque calcification, mural thrombus, stenosis, aneurysm, and inflammation were recorded during an abdominopelvic computed tomography scan. In addition, percentage of the abdominopelvic aorta surface covered by atheromatous plaque was calculated.
The mean age of patients with GD and without GD was 50.81 ± 16.20 and 50.40 ± 12.43, respectively. Patients with GD were more likely to have diabetes mellitus, a higher body mass index (BMI) ( < 0.001), and higher cholesterol ( < 0.01), and low-density lipoprotein-cholesterol ( < 0.02) levels. No significant differences were found between the groups regarding other atherosclerotic risk factors. Patients with GD had significantly higher rates of the vascular risk factors as intima-media thickness, plaque formation, calcification, aneurysm, mural thrombosis, stenosis, and inflammation in all abdominal arterial segments other than aneurysm in the femoral arteries. In addition, patients with GD had severe atheromatous plaques in the abdominal aorta, common iliac, external iliac, and common femoral artery (CFA). In patients with GD, parameters of age, BMI, and systolic and diastolic blood pressure were all correlated with the severity of the atheromatous plaque in abdominal aorta, common iliac, external iliac, and CFA.
We demonstrated a direct relationship between GD and abdominopelvic atheromatous plaque, which is a marker for increased cardiovascular risk, for the first time in the literature. Patients with GD exhibit greater abdominopelvic atherosclerosis and therefore, have a higher risk of cardiovascular disease.
本研究旨在评估腹盆腔动脉粥样斑块，将其作为有无胆结石疾病（GD）患者心脏风险的标志物。
本横断面研究共纳入136例患者。48例患者患有GD，其余88例患者未患GD。腹部超声检查时记录有无胆结石，而在腹盆腔计算机断层扫描期间记录血管危险因素，如斑块形成、内膜中层厚度、斑块钙化、壁血栓、狭窄、动脉瘤和炎症。此外，计算动脉粥样斑块覆盖的腹盆腔主动脉表面百分比。
患有GD和未患GD的患者平均年龄分别为50.81±16.20岁和50.40±12.43岁。患有GD的患者更易患糖尿病，体重指数（BMI）更高（<0.001），胆固醇水平更高（<0.01），低密度脂蛋白胆固醇水平更高（<0.02）。两组在其他动脉粥样硬化危险因素方面未发现显著差异。患有GD的患者在除股动脉动脉瘤外的所有腹段动脉中，内膜中层厚度、斑块形成、钙化、动脉瘤、壁血栓形成、狭窄和炎症等血管危险因素发生率显著更高。此外，患有GD的患者在腹主动脉、髂总动脉、髂外动脉和股总动脉（CFA）中存在严重动脉粥样斑块。在患有GD的患者中，年龄、BMI以及收缩压和舒张压参数均与腹主动脉、髂总动脉、髂外动脉和CFA中动脉粥样斑块的严重程度相关。
我们首次在文献中证明了GD与腹盆腔动脉粥样斑块之间存在直接关系，腹盆腔动脉粥样斑块是心血管风险增加的标志物。患有GD的患者表现出更严重的腹盆腔动脉粥样硬化，因此心血管疾病风险更高。
