急性磷化铝中毒时血乳酸水平的变化趋势
Trend of blood lactate level in acute aluminum phosphide poisoning.
作者信息
Erfantalab Peyman, Soltaninejad Kambiz, Shadnia Shahin, Zamani Nasim, Hassanian-Moghaddam Hossein, Mahdavinejad Arezou, Damaneh Behrooz Hashemi
机构信息
Toxicological Research Center, Excellent Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Forensic Toxicology, Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
出版信息
World J Emerg Med. 2017;8(2):116-120. doi: 10.5847/wjem.j.1920-8642.2017.02.006.
BACKGROUND
Aluminum phosphide (AlP) poisoning is common in the developing countries. There is no specific antidote for the treatment of acute AlP poisoning. Early diagnosis of poisoning and outcome predictors may facilitate treatment decisions. The objective of this study was to determine the trend of blood lactate level in acute AlP poisoning to evaluate its role as a prognostic factor.
METHODS
This was a prospective study on acute AlP intoxicated patients during one year. Demographic data, clinical and laboratory data on admission, and outcome were recorded in a self-made questionnaire. Blood lactate levels were analyzed every two hours for 24 hours.
RESULTS
Thirty-nine (27 male, 12 female) patients were included in the study. The mortality rate was 38.5%. The mean blood pressure, pulse rate, blood pH and serum bicarbonate level were significantly different between the survivors and non-survivors groups. Blood lactate level was significantly higher in the non-survivors group during 8 to 16 hours post ingestion.
CONCLUSION
Blood lactate level could be used as an index of severity of acute AlP poisoning.
背景
磷化铝（AlP）中毒在发展中国家很常见。目前尚无治疗急性AlP中毒的特效解毒剂。中毒的早期诊断和预后预测因素可能有助于治疗决策。本研究的目的是确定急性AlP中毒患者血乳酸水平的变化趋势，以评估其作为预后因素的作用。
方法
这是一项对急性AlP中毒患者进行的为期一年的前瞻性研究。通过自制问卷记录患者的人口统计学数据、入院时的临床和实验室数据以及预后情况。在24小时内每两小时分析一次血乳酸水平。
结果
本研究共纳入39例患者（27例男性，12例女性）。死亡率为38.5%。幸存者和非幸存者组之间的平均血压、脉搏率、血液pH值和血清碳酸氢盐水平存在显著差异。摄入后8至I6小时，非幸存者组的血乳酸水平显著更高。
结论
血乳酸水平可作为急性AlP中毒严重程度的指标。
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