Tanriverdi Taner, Kemerdere Rahsan, Inal Berrin B, Yuksel Odhan, Emre Humeyra O, Ahmedov Merdin, Baran Oguz, Ates Seda
Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
Clinical Biochemistry Laboratory, Haseki Training and Research Hospital, Istanbul, Turkey.
Surg Neurol Int. 2017 Mar 14;8:32. doi: 10.4103/sni.sni_405_16. eCollection 2017.
Endocan has been shown to be a marker for several cancers and may show degree of malignancy. The aim of this study is to assess serum levels of endocan before and after surgery on low-grade gliomas (LGGs).
Endocan was assayed by commercially available enzyme-linked immunosorbent assay (ELISA) kits in a total of 19 patients and 12 controls. Serial serum samples were obtained before and after surgery (1 day, 1 week, and 1 month of surgery). Control samples were collected from cord blood during cesarean section. The results were compared with control brain tissues.
Controls showed significantly lower serum endocan levels compared to before and after surgery ( < 0.05). There is a trend of increase in mean serum levels from before surgery and during the very early period after surgery (during first week); however, in the first month, mean serum levels became lower.
Endocan, a vital molecule for angiogenesis, is highly expressed before and after surgery in LGGs, but long-term data is needed. Furthermore, future studies should include high-grade gliomas to discuss whether endocan is associated with recurrence and response to treatment.
内皮糖蛋白已被证明是几种癌症的标志物，可能显示恶性程度。本研究的目的是评估低级别胶质瘤（LGG）手术前后血清内皮糖蛋白水平。
采用市售酶联免疫吸附测定（ELISA）试剂盒对19例患者和12例对照者进行内皮糖蛋白检测。在手术前后（术后1天、1周和1个月）采集系列血清样本。对照样本取自剖宫产术中的脐血。将结果与对照脑组织进行比较。
与手术前后相比，对照者血清内皮糖蛋白水平显著降低（<0.05）。从手术前到术后早期（第一周），平均血清水平有升高趋势；然而，在第一个月，平均血清水平降低。
内皮糖蛋白是血管生成的重要分子，在LGG手术前后高度表达，但需要长期数据。此外，未来的研究应纳入高级别胶质瘤，以探讨内皮糖蛋白是否与复发及治疗反应相关。
