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Impaired AMPK Activity Drives Age-Associated Acute Lung Injury after Hemorrhage.

作者信息

Southern Brian D, Scheraga Rachel G, Olman Mitchell A

机构信息

1 Cleveland Clinic Respiratory Institute Lerner Research Institute Department of Pathobiology Cleveland, Ohio.

出版信息

Am J Respir Cell Mol Biol. 2017 May;56(5):553-555. doi: 10.1165/rcmb.2017-0023ED.

DOI:10.1165/rcmb.2017-0023ED
PMID:28459384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5449495/
Abstract
摘要

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本文引用的文献

1
Age-Dependent Changes in AMPK Metabolic Pathways in the Lung in a Mouse Model of Hemorrhagic Shock.失血性休克小鼠模型中肺脏AMPK代谢途径的年龄依赖性变化
Am J Respir Cell Mol Biol. 2017 May;56(5):585-596. doi: 10.1165/rcmb.2016-0118OC.
2
Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1.腺苷酸活化蛋白激酶（AMPK）的激活通过上调过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC1α）和超氧化物歧化酶1（SOD1）减轻脂多糖（LPS）诱导的急性肺损伤。
Exp Ther Med. 2016 Sep;12(3):1551-1555. doi: 10.3892/etm.2016.3465. Epub 2016 Jun 17.
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Regulation and function of AMPK in physiology and diseases.AMPK在生理和疾病中的调节作用及功能
Exp Mol Med. 2016 Jul 15;48(7):e245. doi: 10.1038/emm.2016.81.
4
Sirt1 and the Mitochondria.沉默调节蛋白1与线粒体
Mol Cells. 2016 Feb;39(2):87-95. doi: 10.14348/molcells.2016.2318. Epub 2016 Feb 2.
5
Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.中性粒细胞衍生的基质金属蛋白酶-8驱动人类肺结核中依赖AMPK的基质破坏。
PLoS Pathog. 2015 May 21;11(5):e1004917. doi: 10.1371/journal.ppat.1004917. eCollection 2015 May.
6
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.高龄与严重创伤失血性休克患者的预后恶化及独特的基因组反应相关。
Crit Care. 2015 Mar 4;19(1):77. doi: 10.1186/s13054-015-0788-x.
7
High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1).高二氧化碳水平通过AMP激活蛋白激酶（AMPK）、叉头转录因子O3a（FoxO3a）蛋白和肌肉特异性泛素连接酶1（MuRF1）导致骨骼肌萎缩。
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8
Role of AMP-Activated Protein Kinase (AMPK) in Smoking-Induced Lung Inflammation and Emphysema.AMP激活蛋白激酶（AMPK）在吸烟诱导的肺部炎症和肺气肿中的作用
Tuberc Respir Dis (Seoul). 2015 Jan;78(1):8-17. doi: 10.4046/trd.2015.78.1.8. Epub 2015 Jan 29.
9
Adenosine monophosphate-activated protein kinase is required for pulmonary artery smooth muscle cell survival and the development of hypoxic pulmonary hypertension.一磷酸腺苷激活蛋白激酶对于肺动脉平滑肌细胞的存活和低氧性肺动脉高压的发展是必需的。
Am J Respir Cell Mol Biol. 2013 Oct;49(4):609-18. doi: 10.1165/rcmb.2012-0446OC.
10
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal.利用 cBioPortal 进行复杂癌症基因组学和临床特征的综合分析
Sci Signal. 2013 Apr 2;6(269):pl1. doi: 10.1126/scisignal.2004088.