Comes Mercè, Rosa Adriane, Reinares Maria, Torrent Carla, Vieta Eduard
*Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain; †Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre; ‡Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre; and §Bipolar Disorders Program and INCT for Translational Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.
J Nerv Ment Dis. 2017 Jun;205(6):443-447. doi: 10.1097/NMD.0000000000000683.
Data describing bipolar disorder in older adults people are scarce, particularly with regard to functional status. This observational, comparative study assessed psychosocial functioning in 33 euthymic older adults with bipolar disorder compared with 30 healthy controls. In addition, we evaluated the association between clinical variables and poor functioning in the patient group. The mean age of the group was 68.70 years. Patients with bipolar disorder experienced poorer psychosocial functioning (19.15 ± 11.36) than healthy controls (5.17 ± 3.72; p = 0.0001), as assessed using the Functioning Assessment Short Test. Significant differences between the groups were found for specific domains of functioning: autonomy, occupational functioning, cognitive functioning, financial issues, and interpersonal relationships (p = 0.0001, respectively). The largest variation was observed in overall functioning (Cohen's d = 0.63). The number of previous hospitalizations was strongly associated with poor overall functioning (F = 7.217, p = 0.002). Older patients with bipolar disorder had a greater functional impairment than the healthy control group. Implementation of novel rehabilitation models is critical to help patients manage their illness.
关于老年双相情感障碍患者的数据稀缺，尤其是在功能状态方面。这项观察性比较研究评估了33名处于心境正常期的老年双相情感障碍患者与30名健康对照者的心理社会功能。此外，我们还评估了患者组中临床变量与功能不良之间的关联。该组的平均年龄为68.70岁。使用功能评估简短测试评估发现，双相情感障碍患者的心理社会功能（19.15±11.36）比健康对照者（5.17±3.72；p = 0.0001）差。在功能的特定领域中发现两组之间存在显著差异：自主性、职业功能、认知功能、财务问题和人际关系（p分别为0.0001）。在总体功能方面观察到最大差异（科恩d值 = 0.63）。既往住院次数与总体功能不良密切相关（F = 7.217，p = 0.002）。老年双相情感障碍患者的功能损害比健康对照组更大。实施新型康复模式对于帮助患者管理疾病至关重要。
