慢性尿毒症患者血小板中的腺苷酸环化酶和α-2-肾上腺素能受体

Adenylate cyclase and alpha-2-adrenoceptors in thrombocytes of chronic uremic patients.

作者信息

Lübbecke F, Sandelbaum J, Schütterle G, Wizemann V

机构信息

Center of Internal Medicine, Justus Liebig University, Giessen, FRG.

出版信息

Blood Purif. 1988;6(5):269-75. doi: 10.1159/000169554.

DOI:10.1159/000169554

PMID:2846009

Abstract

Thrombocyte adenylate cyclase regulation and alpha-2-adrenoceptors have been studied in uremic patients as well as in healthy controls. Stimulation of adenylate cyclase activity by PGE1 and forskolin as well as inhibition by (+/-)-epinephrine was not significantly different between both groups. Additionally, there was no evidence of an alteration of the thrombocyte alpha-2-adrenoceptor density, determined by 3H-rauwolscine binding as suggested by others.

摘要

已对尿毒症患者和健康对照者的血小板腺苷酸环化酶调节及α-2肾上腺素能受体进行了研究。两组之间，PGE1和福斯高林对腺苷酸环化酶活性的刺激以及（±）-肾上腺素对其的抑制均无显著差异。此外，正如其他人所指出的，通过3H-萝芙辛结合测定，没有证据表明血小板α-2肾上腺素能受体密度发生改变。