Kholodenko B N, Zhilinskene V Iu, Borutaĭte V I, Ivanovene L I, Toleĭkis A I
Biokhimiia. 1988 Jun;53(6):1009-12.
The regulatory role of adenine nucleotide translocase in oxidative phosphorylation was determined by titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the creatine phosphokinase ADP-regenerating system, which is not rate-limiting. It was found that the respiration rate is not controlled by adenine nucleotide translocase in states 3 and 4. Within the physiological region of respiration (30-70% of the maximal rate), the control coefficient for ADP/ATP translocase is 0.62-0.75. Thus, translocase plays a key role in the regulation of oxidative phosphorylation.
在肌酸磷酸激酶ADP再生系统（该系统不是限速环节）中，通过用羧基苍术苷滴定分离的兔心脏线粒体的呼吸作用，确定了腺嘌呤核苷酸转位酶在氧化磷酸化中的调节作用。结果发现，在状态3和状态4下，呼吸速率不受腺嘌呤核苷酸转位酶的控制。在呼吸作用的生理范围内（最大速率的30%-70%），ADP/ATP转位酶的控制系数为0.62-0.75。因此，转位酶在氧化磷酸化的调节中起关键作用。
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