桥本甲状腺炎中的BREG细胞与其他器官特异性自身免疫性疾病相关或与之分离。
BREG cells in Hashimoto's thyroiditis isolated or associated to further organ-specific autoimmune diseases.
作者信息
Santaguida Maria Giulia, Gatto Ilenia, Mangino Giorgio, Virili Camilla, Stramazzo Ilaria, Fallahi Poupak, Antonelli Alessandro, Segni Maria, Romeo Giovanna, Centanni Marco
机构信息
Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Italy.
出版信息
Clin Immunol. 2017 Nov;184:42-47. doi: 10.1016/j.clim.2017.04.012. Epub 2017 Apr 28.
Hashimoto thyroiditis (HT) may occur isolated or associated with other non-endocrine autoimmune disorders (NEAD). No data are available about Breg cells in these disorders and this represented the aim of the study. Th17 and Breg cells subset were characterized on peripheral blood mononuclear cells isolated from 18 healthy donors (HD), 19 patients with isolated HT and 26 patients with HT+NEAD. Th17 were higher in patients with isolated HT than in HD but no further changes were seen in patients with HT+NEAD. CD24CD38 unstimulated Breg cells were similar in HT patients and in HD, but significantly higher in patients with HT+NEAD than in both HT and in HD. CD19CD24CD27 Breg memory phenotype was similar in HD and in HT patients, but decreased in patients with HT+NEAD (23.4%vs38.5%). Upon CpG-stimulation, CD24CD38 IL-10 Breg cells were higher in HT patients than in HD (3.9%vs1.8%) but similar in patients with HT+NEAD (2.4%).
桥本甲状腺炎（HT）可单独发生，也可与其他非内分泌自身免疫性疾病（NEAD）相关。目前尚无关于这些疾病中调节性B细胞（Breg细胞）的数据，这也是本研究的目的所在。对从18名健康供者（HD）、19名孤立性HT患者和26名HT合并NEAD患者中分离出的外周血单个核细胞进行了Th17和Breg细胞亚群的特征分析。孤立性HT患者的Th17细胞高于HD，但HT合并NEAD患者未见进一步变化。未刺激的CD24CD38 Breg细胞在HT患者和HD中相似，但在HT合并NEAD患者中显著高于HT患者和HD。HD和HT患者的CD19CD24CD27 Breg记忆表型相似，但在HT合并NEAD患者中降低（23.4%对38.5%）。在CpG刺激后，HT患者的CD24CD38 IL-10 Breg细胞高于HD（3.9%对1.8%），但在HT合并NEAD患者中相似（2.4%）。
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