Dai Ning, Shi Qi-Hao, Zheng Long-Wei, Huang Xiao-Shan, Fan Shu-Feng
The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Med Sci Monit. 2025 Jul 10;31:e947862. doi: 10.12659/MSM.947862.
BACKGROUND Hashimoto's thyroiditis is a common autoimmune disease. There are currently few studies utilizing multi-parametric magnetic resonance imaging (MRI) to investigate diffuse thyroid lesions such as Hashimoto's thyroiditis. This study aims to explore the value of multi-parametric MRI in assessing the progression of Hashimoto's thyroiditis. MATERIAL AND METHODS The study ultimately included 40 patients with Hashimoto's thyroiditis, who were randomly and evenly assigned to an intervention group and a control group. The intervention group received dietary management, while the control group received no intervention. Laboratory and imaging tests were conducted at baseline and 6 months later. RESULTS After dietary management, patients with Hashimoto's thyroiditis showed a significant reduction in thyroid T2-weighted imaging relative signal intensity (T2WI RSI) (mean: 1.69±0.35 vs 1.42±0.24, P<0.05) and water fraction (mean: 94.57±1.76 vs 93.36±1.62, P<0.001). Additionally, thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) levels decreased significantly (TPOAb: 376.58±319.52 vs 273.55±287.63, P<0.05; TGAb: 219.06±572.54 vs 198.80±567.59, P<0.05). In contrast, no significant changes in thyroid water fraction, TPOAb, or TGAb levels were observed in the control group (P>0.05). CONCLUSIONS In conclusion, multi-parametric MRI offers a valuable quantitative tool for assessing Hashimoto's thyroiditis, providing an intuitive and sensitive method to improve disease understanding and management.
背景 桥本甲状腺炎是一种常见的自身免疫性疾病。目前利用多参数磁共振成像（MRI）研究桥本甲状腺炎等弥漫性甲状腺病变的研究较少。本研究旨在探讨多参数MRI在评估桥本甲状腺炎病情进展中的价值。
材料与方法 本研究最终纳入40例桥本甲状腺炎患者，将其随机平均分为干预组和对照组。干预组接受饮食管理，而对照组不接受干预。在基线和6个月后进行实验室和影像学检查。
结果 经过饮食管理后，桥本甲状腺炎患者的甲状腺T2加权成像相对信号强度（T2WI RSI）显著降低（均值：1.69±0.35对1.42±0.24，P<0.05），水分含量也显著降低（均值：94.57±1.76对93.36±1.62，P<0.001）。此外，甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TGAb）水平显著下降（TPOAb：376.58±319.52对273.55±287.63，P<0.05；TGAb：219.06±572.54对198.80±567.59，P<0.05）。相比之下，对照组的甲状腺水分含量、TPOAb或TGAb水平未观察到显著变化（P>0.05）。
结论 总之，多参数MRI为评估桥本甲状腺炎提供了一种有价值的定量工具，为提高对疾病的认识和管理提供了一种直观且敏感的方法。
