Hippo 通路在肝细胞癌中的作用：非编码 RNA 的作用。
The Hippo pathway in hepatocellular carcinoma: Non-coding RNAs in action.
机构信息
Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Institute of Liver Disease, Zhongshan Hospital of Fudan University, Shanghai, China; Key Laboratory of Medical Molecular Virology, Shanghai Medical College of Fudan University, Shanghai, China.
出版信息
Cancer Lett. 2017 Aug 1;400:175-182. doi: 10.1016/j.canlet.2017.04.032. Epub 2017 Apr 29.
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related death worldwide. However, current strategies curing HCC are far from satisfaction. The Hippo pathway is an evolutionarily conserved tumor suppressive pathway that plays crucial roles in organ size control and tissue homeostasis. Its dysregulation is commonly observed in various types of cancer including HCC. Recently, the prominent role of non-coding RNAs in the Hippo pathway during normal development and neoplastic progression is also emerging in liver. Thus, further investigation into the regulatory network between non-coding RNAs and the Hippo pathway and their connections with HCC may provide new therapeutic avenues towards developing an effective preventative or perhaps curative treatment for HCC. Herein we summarize the role of non-coding RNAs in the Hippo pathway, with an emphasis on their contribution to carcinogenesis, diagnosis, treatment and prognosis of HCC.
肝细胞癌 (HCC) 是全球第六大常见癌症，也是癌症相关死亡的第三大主要原因。然而，目前治疗 HCC 的策略远不能令人满意。Hippo 通路是一种进化上保守的肿瘤抑制通路，在器官大小控制和组织稳态中发挥着关键作用。其失调在包括 HCC 在内的各种类型的癌症中很常见。最近，非编码 RNA 在 Hippo 通路在正常发育和肿瘤进展中的重要作用也在肝脏中显现出来。因此，进一步研究非编码 RNA 与 Hippo 通路之间的调控网络及其与 HCC 的关系，可能为开发有效的 HCC 预防性或治疗性治疗方法提供新的治疗途径。本文总结了非编码 RNA 在 Hippo 通路中的作用，重点介绍了它们在 HCC 发生、诊断、治疗和预后中的作用。
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