Qiu Lipeng, Tang Qi, Li Guohui, Chen Keping
Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province 212013, China.
Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province 212013, China.
Life Sci. 2017 Dec 15;191:273-282. doi: 10.1016/j.lfs.2017.10.007. Epub 2017 Oct 4.
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer worldwide, and the survival rates of patients with HCC remains quite low after 5years. Long non-coding RNAs (LncRNAs) are a novel class of non-coding RNAs that are capable of regulating gene expression at various levels. Recent works have demonstrated that lncRNAs are often dysregulated in HCC, and the dysregulation of some of these lncRNAs are associated with the clinicopathological features of HCC. They regulate cell proliferation, apoptosis, autophagy, Epithelial-Mesenchymal Transition (EMT), invasion and metastasis of HCC by modulating gene expression and cancer-related signaling pathways, and thus contribute to the onset and progression of HCC. In this review, we provide a comprehensive survey of dysregulated lncRNAs in HCC, with particular focus on the functions and regulatory mechanisms of several essential and important lncRNAs, and discuss their potential clinical application as early diagnostic and/or prognostic biomarkers or therapeutic targets for HCC.
肝细胞癌（HCC）是全球最常见的原发性肝癌，HCC患者5年后的生存率仍然很低。长链非编码RNA（LncRNAs）是一类新型的非编码RNA，能够在多个水平上调节基因表达。最近的研究表明，lncRNAs在HCC中常常失调，其中一些lncRNAs的失调与HCC的临床病理特征有关。它们通过调节基因表达和癌症相关信号通路来调节HCC的细胞增殖、凋亡、自噬、上皮-间质转化（EMT）、侵袭和转移，从而促进HCC的发生和发展。在本综述中，我们全面综述了HCC中失调的lncRNAs，特别关注几种重要lncRNAs的功能和调控机制，并讨论它们作为HCC早期诊断和/或预后生物标志物或治疗靶点的潜在临床应用。
