Department of Biochemistry, Center for Regulatory Epigenome and Diseases, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan.
Nat Rev Immunol. 2017 Jul;17(7):437-450. doi: 10.1038/nri.2017.26. Epub 2017 May 2.
BTB and CNC homology (BACH) proteins are transcriptional repressors of the basic region leucine zipper (bZIP) transcription factor family. Recent studies indicate widespread roles of BACH proteins in controlling the development and function of the innate and adaptive immune systems, including the differentiation of effector and memory cells of the B and T cell lineages, CD4 regulatory T cells and macrophages. Here, we emphasize similarities at a molecular level in the cell-type-specific activities of BACH factors, proposing that competitive interactions of BACH proteins with transcriptional activators of the bZIP family form a common mechanistic theme underlying their diverse actions. The findings contribute to a general understanding of how transcriptional repressors shape lineage commitment and cell-type-specific functions through repression of alternative lineage programmes.
BTB 和 CNC 同源 (BACH) 蛋白是碱性亮氨酸拉链 (bZIP) 转录因子家族的转录抑制剂。最近的研究表明，BACH 蛋白在控制先天和适应性免疫系统的发育和功能方面发挥着广泛的作用，包括 B 和 T 细胞谱系效应和记忆细胞的分化、CD4 调节性 T 细胞和巨噬细胞。在这里，我们强调了 BACH 因子在细胞类型特异性活性方面的分子水平相似性，提出 BACH 蛋白与 bZIP 家族转录激活剂的竞争相互作用形成了其多样化作用的共同机制主题。这些发现有助于人们普遍了解转录抑制剂如何通过抑制替代谱系程序来塑造谱系承诺和细胞类型特异性功能。
