Dowling N M, Khramtsova Galina, Olopade Olufunmilayo, Samankan Shabnam, Lee Bok-Soon, Lee Jiyoung
Department of Acute & Chronic Care, School of Nursing, Ashburn, VA 20147, USA.
Department of Epidemiology, Milken Institute School of Public Health, Washington, DC 20037, USA.
Curr Oncol. 2025 Jul 14;32(7):404. doi: 10.3390/curroncol32070404.
BACH1 has been identified as a functional regulator of cancer metastasis and metabolic signaling in breast cancer cells. However, the clinical relevance of BACH1 expression in breast tumors remains poorly understood. Using a tissue microarray from a cohort of 130 patients, we assessed the expression of BACH1 and its known target gene, MCT1 (encoded by ), through immunohistochemistry (IHC). The expression data were then analyzed in relation to clinical variables, including breast cancer subtypes, tissue types, tumor size and grade, patient racial background, and age group. We found positive associations between BACH1 expression and tumor size, tumor grade, and the basal-like subtype. Importantly, BACH1 expression was significantly higher in tumors from Black women compared to those from White women, as well as in the basal-like subtype of breast tumors from Black women. Additionally, a positive correlation was observed between BACH1 and MCT1 IHC scores in tumors from Black women, while a weak association was noted in tumors from White women. Our study provides compelling evidence that BACH1 expression is evident based on the race and subtypes of breast cancer patients.
BACH1已被确定为乳腺癌细胞中癌症转移和代谢信号的功能调节因子。然而，BACH1在乳腺肿瘤中的表达与临床的相关性仍知之甚少。我们使用来自130名患者队列的组织微阵列，通过免疫组织化学（IHC）评估了BACH1及其已知靶基因MCT1（由 编码）的表达。然后将表达数据与临床变量进行分析，这些临床变量包括乳腺癌亚型、组织类型、肿瘤大小和分级、患者种族背景以及年龄组。我们发现BACH1表达与肿瘤大小、肿瘤分级和基底样亚型之间存在正相关。重要的是，与白人女性的肿瘤相比，黑人女性肿瘤中的BACH1表达明显更高，在黑人女性的基底样亚型乳腺肿瘤中也是如此。此外，在黑人女性的肿瘤中观察到BACH1和MCT1 IHC评分之间呈正相关，而在白人女性的肿瘤中则发现弱相关性。我们的研究提供了令人信服的证据，表明基于乳腺癌患者的种族和亚型，BACH1表达是明显的。
