Dimsdale J, Ziegler M, Graham R
University of California, San Diego.
Clin Exp Hypertens A. 1988;10(5):747-56. doi: 10.1080/07300077.1988.11878781.
The heart rate response to isoproterenol is felt to be an index of beta receptor sensitivity. We studied this response in 55 normotensive and mildly hypertensive men on two dietary salt intakes (10 meq sodium per day, and 200 meq sodium per day). There was no relationship between receptor functioning and diagnosis of hypertension. Similarly, age, relative body weight, and resting plasma catecholamines were unrelated to the heart rate response to isoproterenol. There was however, a significant three-way interaction between race, diagnosis, and dietary salt. Black hypertensives fail to down regulate their beta receptors' response to isoproterenol in the face of a high salt challenge (p less than .006).
心率对异丙肾上腺素的反应被认为是β受体敏感性的一个指标。我们在55名血压正常和轻度高血压男性中，就两种饮食盐摄入量（每天10毫当量钠和每天200毫当量钠）研究了这种反应。受体功能与高血压诊断之间没有关系。同样，年龄、相对体重和静息血浆儿茶酚胺与心率对异丙肾上腺素的反应无关。然而，种族、诊断和饮食盐之间存在显著的三因素交互作用。面对高盐刺激时，黑人高血压患者无法下调其β受体对异丙肾上腺素的反应（p小于0.006）。
