Mattei M G, Sardet C, Franchi A, Pouysségur J
INSERM U242, Centre de Génétique Médicale, Hôpital d'enfants de la Timone, Marseille, France.
Cytogenet Cell Genet. 1988;48(1):6-8. doi: 10.1159/000132575.
The Na+/H+ antiporter is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. We cloned the human gene capable of complementing antiporter-deficient mouse fibroblasts and isolated an exon-containing genomic DNA fragment. Using this genomic probe, we mapped the putative structural gene of the amiloride-sensitive Na+/H+ antiporter to the human chromosome region 1p35----p36.1 by in situ hybridization.
