1 Department of Psychiatry, University of Milan, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy.
2 Cantonal Psychiatric Clinic, Mendrisio, Switzerland.
J Psychopharmacol. 2017 Dec;31(12):1537-1543. doi: 10.1177/0269881117705098. Epub 2017 May 2.
Available antipsychotics show different efficacy on manic symptoms of bipolar patients, but few studies have investigated the speed of action of the various compounds. For this reason, purpose of the present paper was to compare antipsychotic mono-therapies in terms of speed of action in a sample of manic bipolar patients. In total, 155 bipolar patients, treated with antipsychotic mono-therapy and followed-up in Inpatient Psychiatry Clinic of University of Milan, were included in this single-blind comparative study. Clinical response was defined as a reduction of Young Mania Rating Scale (YMRS) scores ⩾50%, while remission as a YMRS score <10. After 4 days patients who had been treated with asenapine, were more likely to have achieved a clinical response than those in treatment with haloperidol ( p = 0.001). After 7 days, a more frequent clinical response was achieved by patients treated with asenapine than those who had been treated with haloperidol ( p < 0.001) or olanzapine ( p = 0.047). Asenapine appears to be faster in determining treatment response in manic patients compared with haloperidol and less markedly with olanzapine.
现有的抗精神病药物在治疗双相情感障碍患者的躁狂症状方面显示出不同的疗效，但很少有研究调查各种化合物的作用速度。出于这个原因，本文的目的是比较单药治疗的抗精神病药物在躁狂双相情感障碍患者样本中的作用速度。共有 155 名接受抗精神病药物单药治疗并在米兰大学精神病住院诊所接受随访的双相情感障碍患者纳入了这项单盲比较研究。临床反应定义为 Young 躁狂评定量表 (YMRS) 评分降低 ⩾50%，而缓解定义为 YMRS 评分 <10。在第 4 天，接受阿塞那平治疗的患者比接受氟哌啶醇治疗的患者更有可能达到临床反应 ( p = 0.001)。第 7 天，接受阿塞那平治疗的患者比接受氟哌啶醇 ( p < 0.001) 或奥氮平 ( p = 0.047) 治疗的患者更频繁地达到临床反应。与氟哌啶醇相比，阿塞那平在确定躁狂患者的治疗反应方面似乎更快，与奥氮平相比则不那么明显。
