Ciancaglini Matías, Bellomo Carla M, Torres Cabreros Clara L, Alonso Daniel, Bassi Sabrina C, Iglesias Ayelén A, Martínez Valeria P
Laboratorio Nacional de Referencia de Hantavirus, Servicio de Biología Molecular, Departamento de Virología, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr. Carlos G. Malbrán, Argentina. E-mail:
Laboratorio Nacional de Referencia de Hantavirus, Servicio de Biología Molecular, Departamento de Virología, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr. Carlos G. Malbrán, Argentina.
Medicina (B Aires). 2017;77(2):81-84.
We describe the characterization of the viral genotype involved in the first case of hantavirus pulmonary syndrome reported in Tucumán, a Northwestern province of Argentina. A 23-year-old woman, with no record of travel history and previously diagnosed with an antiphospholipid syndrome, died after 11 days of severe cardiopulmonary insufficiency. Among the four endemic regions of hantavirus pulmonary syndrome in Argentina, the Northwest Region has the highest incidence, exceeding 50% of all reported cases in the country. Until now, only Salta and Jujuy (2 out of the 6 provinces composing the Northwest Region), reported cases of hantavirus pulmonary syndrome, all of which occurred in the Yungas Forest area. Remarkably, the viral genotype characterized in this case showed higher nucleotide identity with the Andes-BsAs genotype most prevalent in Buenos Aires province, located 1400 km apart from Tucumán, than with any of the commonly found genotypes in the Northwest Region. The Andes-BsAs genotype has been associated with 30% lethality and interhuman transmission in Buenos Aires province. Interhuman transmission cannot be ruled out in the present case.
我们描述了阿根廷西北部图库曼省报告的首例汉坦病毒肺综合征病例所涉及的病毒基因型特征。一名23岁女性，无旅行史记录，此前被诊断患有抗磷脂综合征，在出现严重心肺功能不全11天后死亡。在阿根廷汉坦病毒肺综合征的四个流行地区中，西北地区发病率最高，超过全国报告病例总数的50%。到目前为止，只有萨尔塔省和胡胡伊省（构成西北地区的6个省份中的2个）报告过汉坦病毒肺综合征病例，所有病例均发生在云加斯森林地区。值得注意的是，该病例中鉴定出的病毒基因型与距离图库曼1400公里的布宜诺斯艾利斯省最常见的安第斯 - 布宜诺斯艾利斯基因型相比，与西北地区任何常见基因型的核苷酸同源性更高。安第斯 - 布宜诺斯艾利斯基因型在布宜诺斯艾利斯省与30%的致死率和人际传播有关。本案不能排除人际传播的可能性。
