Martínez V P, Colavecchia S, García Alay M, Suzuki B, Trincheri A, Busto S, Rabinovich R, Padula P
Laboratorio de Hantavirus, Servicio de Biología Molecular, Departamento de Virus, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr. Carlos G. Malbrán, Buenos Aires.
Medicina (B Aires). 2001;61(2):147-56.
In Argentina the first Hantavirus Pulmonary Syndrome (HPS) cases were characterized in 1995. Since then, Argentina is the country with the highest number of notified cases in South America. The disease is distributed in Northern, Southern and Central regions of the country, being Buenos Aires the most affected province from the Central region. In this study, we present seasonal and geographical distribution of HPS cases in Buenos Aires province, the association with diverse viral lineages and the serological characteristics of hantavirus infection in the period from 1997 up to the first semester of the year 2000. An increase in the number of HPS cases was observed up to 1999 and a gradual mortality decrease in the whole period. The cases occurred between spring and autumn, with a maximum peak in summer. The serological response was studied in 58 HPS confirmed cases at different times after the onset of symptoms. The cases were distributed between 27 localities, in two different directions from the city of Buenos Aires: South-southwest and North-northeast. More than 52% of the cases occurred in La Plata and neighboring localities. The viral genomes from 39 cases were all characterised as Andes virus (AND): AND Cent Plata 16%; AND Cent 21% and AND Cent Bs.As. 60%. Andes virus lineages only cocirculated in La Plata city. These results will contribute to establish a risk map leading to the implementation of improved strategies of prevention.
1995年，阿根廷首次确认了汉坦病毒肺综合征（HPS）病例。自那时起，阿根廷成为南美洲报告病例数最多的国家。该疾病分布在阿根廷的北部、南部和中部地区，布宜诺斯艾利斯省是中部地区受影响最严重的省份。在本研究中，我们呈现了1997年至2000年上半年布宜诺斯艾利斯省HPS病例的季节性和地理分布、与不同病毒谱系的关联以及汉坦病毒感染的血清学特征。观察到直至1999年HPS病例数有所增加，且在整个时期内死亡率逐渐下降。病例发生在春季和秋季之间，夏季达到高峰。对58例确诊的HPS病例在症状出现后的不同时间进行了血清学反应研究。这些病例分布在27个地区，从布宜诺斯艾利斯市向两个不同方向延伸：西南偏南和东北偏北。超过52%的病例发生在拉普拉塔及其周边地区。39例病例的病毒基因组均被鉴定为安第斯病毒（AND）：AND Cent Plata占16%；AND Cent占21%；AND Cent Bs.As.占60%。安第斯病毒谱系仅在拉普拉塔市共同传播。这些结果将有助于绘制风险地图，从而实施改进的预防策略。
