Cherbanyk Floryn, Gassend Jean Loup, Dimitrief Maria, Andrejevic-Blant Snezana, Martinet Olivier, Pezzetta Edgardo
Chirurgia (Bucur). 2017 Mar-Apr;112(2):152-156. doi: 10.21614/chirurgia.112.2.152.
The aim of this paper is to report the clinicopathological data of one case of mixed metastatic adenoneuroendocrine carcinoma (MANEC) in the caecum; less than ten cases of which have been described in the English literature. A 57-year-old male patient presented with a mixed adenoneuroendocrine carcinoma (MANEC) of the caecum with liver metastasis and peritoneal carcinomatosis. An emergency right hemicolectomy and omentectomy were performed, followed by several cycles of unsuccessful palliative chemotherapy. The metastasis developed further, and the patient died 10 months after presenting to the emergency room. MANECs are defined as containing at least 30% of both a neuroendocrine and an adenocarcinomatous component. The location of the tumour and the proportions and behaviour of its two components influence the treatment. However, chemotherapy guidelines remain poorly defined, and prognosis remains sombre, with median survival of less than one year.
本文旨在报告1例盲肠混合性转移性腺神经内分泌癌（MANEC）的临床病理资料；英文文献中描述的此类病例不足10例。一名57岁男性患者出现盲肠混合性腺神经内分泌癌并伴有肝转移和腹膜播散。急诊行右半结肠切除术和大网膜切除术，随后进行了几个周期的姑息性化疗，但均未成功。转移进一步发展，患者在急诊就诊10个月后死亡。MANEC被定义为至少含有30%的神经内分泌成分和腺癌成分。肿瘤的位置及其两种成分的比例和行为会影响治疗。然而，化疗指南仍不明确，预后仍然很差，中位生存期不到一年。
