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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Japan.

Int J Biochem. 1988;20(7):661-6. doi: 10.1016/0020-711x(88)90160-7.

Leukotrienes (LT) constitute a family of bioactive compounds mainly involved in inflammatory and immunological responses. 2. LTs are produced via an unstable intermediate, LTA4 which is synthesized by the action of arachidonate 5-lipoxygenase, a calcium-dependent enzyme. 3. LTA4 is converted to either LTB4 by cytosolic LTA4 hydrolase or to LTC4 by LTC4 synthase present in the microsomal fraction. 4. Three enzymes (5-lipoxygenase, LTA4 hydrolase and LTC4 synthase) were purified, and molecular and kinetic properties have been extensively investigated. 5. The cDNA of LTA4 hydrolase was recently isolated, and the primary structure was fully determined in our laboratory. 6. I report herein recent progress in studies on arachidonic acid metabolism, with the focus primarily on enzymes linked to the 5-lipoxygenase pathway.

白三烯（LT）构成一类主要参与炎症和免疫反应的生物活性化合物家族。2. 白三烯通过不稳定中间体LTA4产生，LTA4由花生四烯酸5-脂氧合酶（一种钙依赖性酶）的作用合成。3. LTA4通过胞质LTA4水解酶转化为LTB4，或通过微粒体部分中存在的LTC4合酶转化为LTC4。4. 三种酶（5-脂氧合酶、LTA4水解酶和LTC4合酶）已被纯化，其分子和动力学特性已得到广泛研究。5. LTA4水解酶的cDNA最近已被分离，其一级结构在我们实验室已完全确定。6. 本文报道了花生四烯酸代谢研究的最新进展，主要侧重于与5-脂氧合酶途径相关的酶。

Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Japan.

Int J Biochem. 1988;20(7):661-6. doi: 10.1016/0020-711x(88)90160-7.

Leukotrienes (LT) constitute a family of bioactive compounds mainly involved in inflammatory and immunological responses. 2. LTs are produced via an unstable intermediate, LTA4 which is synthesized by the action of arachidonate 5-lipoxygenase, a calcium-dependent enzyme. 3. LTA4 is converted to either LTB4 by cytosolic LTA4 hydrolase or to LTC4 by LTC4 synthase present in the microsomal fraction. 4. Three enzymes (5-lipoxygenase, LTA4 hydrolase and LTC4 synthase) were purified, and molecular and kinetic properties have been extensively investigated. 5. The cDNA of LTA4 hydrolase was recently isolated, and the primary structure was fully determined in our laboratory. 6. I report herein recent progress in studies on arachidonic acid metabolism, with the focus primarily on enzymes linked to the 5-lipoxygenase pathway.

白三烯（LT）构成一类主要参与炎症和免疫反应的生物活性化合物家族。2. 白三烯通过不稳定中间体LTA4产生，LTA4由花生四烯酸5-脂氧合酶（一种钙依赖性酶）的作用合成。3. LTA4通过胞质LTA4水解酶转化为LTB4，或通过微粒体部分中存在的LTC4合酶转化为LTC4。4. 三种酶（5-脂氧合酶、LTA4水解酶和LTC4合酶）已被纯化，其分子和动力学特性已得到广泛研究。5. LTA4水解酶的cDNA最近已被分离，其一级结构在我们实验室已完全确定。6. 本文报道了花生四烯酸代谢研究的最新进展，主要侧重于与5-脂氧合酶途径相关的酶。