Lenz H J, Raedler A, Greten H, Vale W W, Rivier J E
Department of Medicine, University of Hamburg, Federal Republic of Germany.
Gastroenterology. 1988 Dec;95(6):1510-7. doi: 10.1016/s0016-5085(88)80070-2.
Corticotropin-releasing factor (CRF) has been implicated as a central nervous system mediator of stress. This study examined the effects of CRF and stress on gastric secretory and gastrointestinal motor functions in rats. Partial body restraint as a stress-producing stimulus significantly decreased gastric acid secretion, gastric emptying, and small bowel transit but markedly increased large bowel transit. Corticotropin-releasing factor given cerebroventricularly mimicked the gastrointestinal secretory and motor responses induced by partial body restraint. Cerebroventricular administration of a specific CRF receptor antagonist, alpha-helical CRF-(9-41), but not of the CRF fragment CRF-(1-20), prevented the gastrointestinal secretory and motor responses elicited either by partial body restraint or by exogenous administration of CRF in a dose-dependent fashion. These results suggest that the gastrointestinal secretory and motor responses in rats produced by stress (partial body restraint) are mediated by the endogenous release of CRF. They also indicate that CRF exerts its central nervous system actions on the gastrointestinal tract by a receptor-mediated event.
促肾上腺皮质激素释放因子（CRF）被认为是应激反应的中枢神经系统介质。本研究检测了CRF和应激对大鼠胃分泌及胃肠运动功能的影响。部分身体束缚作为一种应激刺激，显著降低胃酸分泌、胃排空及小肠转运，但显著增加大肠转运。脑室内注射促肾上腺皮质激素释放因子模拟了部分身体束缚诱导的胃肠分泌及运动反应。脑室内注射特异性CRF受体拮抗剂α-螺旋CRF-（9-41），而非CRF片段CRF-（1-20），以剂量依赖方式阻止了部分身体束缚或外源性注射CRF引起的胃肠分泌及运动反应。这些结果表明，应激（部分身体束缚）引起的大鼠胃肠分泌及运动反应是由内源性释放的CRF介导的。它们还表明，CRF通过受体介导的事件对胃肠道发挥其在中枢神经系统的作用。
