Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Birth Defects Res. 2017 Jul 3;109(11):836-842. doi: 10.1002/bdr2.1025. Epub 2017 May 2.
In the last decades, an increasing rate of gastroschisis but not of omphalocele has been reported worldwide. Greenland is the world's largest island, but 80% is covered by an ice cap, it has a small population of around 56,000 peoples (as of 2016). The occurrence of abdominal wall defects has never been investigated in Greenland.
The present study is based on data retrieved from three nationwide and two local registries in the Greenlandic health care system over 27 years (1989-2015).
We identified 33 infants with abdominal wall defects born in the study time period. All cases were reclassified to 28 cases of gastroschisis, four cases of omphalocele, and there was 1 infant in the indeterminate group. The point prevalence at birth for gastroschisis increased significantly from 8 to 35 (average 10.7) per 10,000 liveborn and -stillborn infants. Mothers below 20 years of age represented 23% of all cases and the prevalence for this group was 17 per 10,000 liveborn and stillborn. Perinatal mortality for infants with gastroschisis was high (18%), and 1 year survival was 71%. For omphalocele, the prevalence varied from 8 to 11 per 10,000 liveborn and stillborn infants. There was no increasing rate in the period, further highlighting an etiological difference between gastroschisis and omphalocele.
This study confirms the increasing prevalence of gastroschisis in Greenland in the period from 1989 to 2015. The average was 10.7 per 10,000 liveborn and -stillborn infants and, to the best of our knowledge, this is the highest prevalence ever reported. Birth Defects Research 109:836-842, 2017. © 2017 Wiley Periodicals, Inc.
在过去几十年中，全世界报道的腹裂发病率不断增加，但脐膨出的发病率却没有增加。格陵兰是世界上最大的岛屿，但 80%的面积被冰盖覆盖，其人口约为 56000 人（截至 2016 年）。格陵兰从未对腹壁缺陷的发生情况进行过调查。
本研究基于在格陵兰医疗保健系统中，通过三个全国性和两个地方性登记处收集的 27 年（1989-2015 年）的数据。
我们确定了 33 名在研究期间出生的患有腹壁缺陷的婴儿。所有病例均重新分类为 28 例腹裂、4 例脐膨出，还有 1 例病例不确定。出生时腹裂的点患病率显著增加，从每 10000 例活产和死产婴儿的 8 例增加到 35 例（平均为 10.7）。年龄在 20 岁以下的母亲占所有病例的 23%，该组的患病率为每 10000 例活产和死产婴儿 17 例。患有腹裂的婴儿围产期死亡率很高（18%），1 年生存率为 71%。脐膨出的患病率从每 10000 例活产和死产婴儿的 8 例到 11 例不等。在此期间没有增加的趋势，这进一步强调了腹裂和脐膨出之间的病因差异。
本研究证实了 1989 年至 2015 年期间格陵兰腹裂发病率的增加。平均每 10000 例活产和死产婴儿 10.7 例，据我们所知，这是有史以来报道的最高患病率。出生缺陷研究 109:836-842, 2017。© 2017 威利父子公司
