Shen Y Y, Chen J C, Li G, Cao J, Li J X, Huang J F, Gu D F
Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2017 May 6;51(5):415-420. doi: 10.3760/cma.j.issn.0253-9624.2017.05.009.
To explore the lipid accumulation product (LAP) formula for Beijing adults and to investigate the relationship between lipid accumulation product and hypertension, as well as diabetes. A cross-sectional study with a representative sample of 19 606 residents in Beijing aged 18-79 years was conducted in 2011. The sex-specific hypothetical minimum waist circumference (WC) was calculated in order to obtain the more applicable LAP formula. Multivariate logistic regression was used to analyze the associations of LAP, combination of LAP and body mass index (BMI) with hypertension and diabetes. The LAP formula for Beijing adults was established as follows: LAP (male)= (WC-61.3) × TG, and LAP (female)= (WC-55.6) × TG. There was an obvious trend of increased risk of hypertension and diabetes with an increment in the tertiles of the LAP both in men and women. The (95%) for hypertension in the group with highest tertile LAP was 3.62 (3.11-4.22) in men, and 5.79 (4.84-6.93) in women, compared with the lowest tertile group, respectively; and the corresponding for diabetes was 3.47 (2.73-4.41) in men, and 4.10 (2.90-5.80) in women, respectively. Compared with the lowest tertile of LAP and normal BMI group, the (95%) for hypertension in the highest tertile of LAP and obesity group was 6.79 (5.50-8.37) in men, and 9.75 (7.76-12.25) in women, respectively; while the corresponding value for diabetes was 3.97 (2.87-5.49) in men, and 4.13 (2.78-6.14) in women, respectively. The elevated level of LAP was associated with an increased risk of hypertension and diabetes among Beijing adults. LAP could be an important predictor for hypertension and diabetes.
探索适用于北京成年人的脂质蓄积产物(LAP)公式,并研究脂质蓄积产物与高血压以及糖尿病之间的关系。2011年对19606名年龄在18 - 79岁的北京居民进行了具有代表性样本的横断面研究。计算了按性别划分的假设最小腰围(WC),以获得更适用的LAP公式。采用多因素逻辑回归分析LAP、LAP与体重指数(BMI)的组合与高血压和糖尿病之间的关联。北京成年人的LAP公式如下:LAP(男性)=(WC - 61.3)×甘油三酯(TG),LAP(女性)=(WC - 55.6)×TG。男性和女性中,随着LAP三分位数的增加,患高血压和糖尿病的风险呈明显上升趋势。与最低三分位数组相比,LAP最高三分位数组男性患高血压的比值比(95%可信区间)为3.62(3.11 - 4.22),女性为5.79(4.84 - 6.93);相应的糖尿病比值比男性为3.47(2.7