Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University, Tehran, Iran.
Lipids Health Dis. 2010 May 10;9:45. doi: 10.1186/1476-511X-9-45.
The body mass index (BMI) is the most commonly used marker for evaluating obesity related risks, however, central obesity measures have been proposed to be more informative. Lipid accumulation product (LAP) is an alternative continuous index of lipid accumulation, which is computed from waist circumference (WC, cm) and triglycerides (TGs, mmol/l): (WC-65) xTG (men) and (WC-58) xTG (women). We sought in this study to assess if LAP can outperform BMI, waist-to-height-ratio (WHtR), or waist-to-hip-ratio (WHpR) in identifying prevalent and predicting incident diabetes.
The cross-sectional analyses were performed on a sample included 3,682 men and 4,989 women who were not pregnant, aged > or = 20 years. According to the age (> or = 50 and <50 years) - and sex-specific analyses, odds ratios (ORs) of LAP for prevalent diabetes were higher than those of BMI, WHpR, or WHtR among women, after adjustment for mean arterial pressure and family history of diabetes. The OR of LAP in old men was lower than those of other adiposity measures; in young men, however, LAP was superior to BMI but identical to WHpR and WHtR in identifying prevalent diabetes. Except in young men, LAP showed highest area under the receiver operating characteristic curves (AROC) for prevalent diabetes (P for trend < or = 0.005). For longitudinal analyses, a total of 5,018 non-diabetic subjects were followed for approximately 6 years. The ORs of BMI, WHpR, and WHtR were the same as those of LAP in both sexes and across age groups; except in young men where LAP was superior to the BMI. AROCs of LAP were relatively the same as anthropometric adiposity measures.
LAP was a strong predictor of diabetes and in young individuals had better predictability than did BMI; it was, however, similar to WHpR and WHtR in prediction of incident diabetes.
体重指数（BMI）是评估肥胖相关风险最常用的指标，但中心性肥胖指标被认为更具信息量。脂质蓄积产物（LAP）是脂质蓄积的替代连续指标，由腰围（WC，cm）和甘油三酯（TGs，mmol/L）计算得出：（WC-65）xTG（男性）和（WC-58）xTG（女性）。我们在这项研究中试图评估 LAP 是否可以在识别现有糖尿病和预测新发糖尿病方面优于 BMI、腰高比（WHtR）或腰臀比（WHpR）。
对包括 3682 名男性和 4989 名未怀孕、年龄≥20 岁的样本进行了横断面分析。根据年龄（≥50 岁和<50 岁）和性别特异性分析，在调整平均动脉压和糖尿病家族史后，女性 LAP 对现有糖尿病的优势比（OR）高于 BMI、WHpR 或 WHtR。老年男性 LAP 的 OR 低于其他肥胖指标；然而，在年轻男性中，LAP 在识别现有糖尿病方面优于 BMI，但与 WHpR 和 WHtR 相同。除年轻男性外，LAP 在识别现有糖尿病方面的受试者工作特征曲线下面积（AUC）最高（趋势 P<0.005）。对于纵向分析，共有 5018 名非糖尿病患者随访了大约 6 年。BMI、WHpR 和 WHtR 的 OR 在男女和各年龄段均与 LAP 相同；除年轻男性外，LAP 优于 BMI。LAP 的 AUC 与人体肥胖指标大致相同。
LAP 是糖尿病的强有力预测指标，在年轻个体中具有比 BMI 更好的预测能力；然而，在预测新发糖尿病方面，LAP 与 WHpR 和 WHtR 相似。
