Kenyon R H, Green D E, Maiztegui J I, Peters C J
Disease Assessment Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Md 21701-5011.
Intervirology. 1988;29(3):133-43. doi: 10.1159/000150039.
Guinea pigs infected with low-passage Junin virus of human origin showed viral strain dependent differences in mortality, LD50, time to death, and in viral spread and distribution. Different Junin strains appeared to cause at least two broad patterns of Argentine hemorrhagic fever in guinea pigs. A number of strains of Junin virus caused a viscerotropic type of illness in which virus replicated predominantly in lymph nodes, spleen, and bone marrow. With the most severe visceral forms of Argentine hemorrhagic fever, the guinea pigs became viremic, developed necrosis of spleen, lymph nodes, and bone marrow, showed gastric hemorrhages, and all animals died within 13-15 days. Other Junin strains induced a neurological type of illness with transient viral replication in and lymphocyte depletion of spleen and lymph nodes, with no detectable viremia or viral replication in bone marrow. Subsequently, virus was found in the brain with varying severities of polioencephalitis, and the guinea pigs frequently showed rear leg paralysis before death occurred 28-34 days after inoculation. Not all animals infected with a neurotropic strain developed all these signs. One viral strain induced some signs characteristic of both patterns of illness. Although the disease forms in the guinea pig model did not strictly correlate with those observed in the humans from which these strains were obtained, the different strains of Junin virus consistently caused very different patterns of illness in infected guinea pigs.
感染低传代人源胡宁病毒的豚鼠在死亡率、半数致死剂量、死亡时间以及病毒传播和分布方面表现出病毒株依赖性差异。不同的胡宁病毒株似乎在豚鼠中引发了至少两种广泛的阿根廷出血热模式。一些胡宁病毒株引发了一种嗜内脏型疾病，病毒主要在淋巴结、脾脏和骨髓中复制。在最严重的阿根廷出血热内脏型病例中，豚鼠出现病毒血症，脾脏、淋巴结和骨髓发生坏死，出现胃出血，所有动物在13 - 15天内死亡。其他胡宁病毒株引发了一种神经型疾病，病毒在脾脏和淋巴结中短暂复制并导致淋巴细胞减少，骨髓中未检测到病毒血症或病毒复制。随后，在大脑中发现病毒，伴有不同严重程度的脑灰质炎，豚鼠在接种后28 - 34天死亡前经常出现后腿麻痹。并非所有感染嗜神经毒株的动物都出现所有这些症状。一种病毒株引发了两种疾病模式的一些特征性症状。尽管豚鼠模型中的疾病形式与从中获得这些毒株的人类中观察到的疾病形式并不严格相关，但不同的胡宁病毒株在感染的豚鼠中始终引发非常不同的疾病模式。
