Sun Xi-Peng, Li Jing, Zhu Wei-Wei, Li Dong-Bao, Chen Hui, Li Hong-Wei, Chen Wen-Ming, Hua Qi
1 Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
2 Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Angiology. 2018 Jan;69(1):71-78. doi: 10.1177/0003319717707410. Epub 2017 May 2.
We investigated the relationship between platelet to lymphocyte ratio (PLR) and contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). We enrolled 5719 patients in 3 tertiary hospitals from January 2005 to December 2010. The PLR was calculated as the ratio of platelet to lymphocyte counts on admission. Serum creatinine level was measured before and within 72 hours after contrast medium administration. To evaluate the relation between PLR and CIN, the 5719 patients were divided into a CIN group and a non-CIN group. Contrast-induced nephropathy occurred in 252 (4.4%) patients. Patients in the CIN group had significantly higher PLR than those in the non-CIN group (173.8 [62.3] and 116.2 [51.7], respectively; P < .001). In logistic regression analysis, PLR was an independent predictor of CIN (odds ratio: 1.432, 95% confidence interval: 1.205-1.816, P = .031), along with age, diabetes mellitus, creatinine, estimated glomerular filtration rate, and neutrophil to lymphocyte ratio. In conclusion, a higher PLR was an independent risk factor for the development of CIN in patients with STEMI undergoing pPCI.
我们研究了接受直接经皮冠状动脉介入治疗（pPCI）的ST段抬高型心肌梗死（STEMI）患者的血小板与淋巴细胞比值（PLR）与造影剂肾病（CIN）之间的关系。我们在2005年1月至2010年12月期间纳入了3家三级医院的5719例患者。PLR计算为入院时血小板与淋巴细胞计数之比。在给予造影剂之前和之后72小时内测量血清肌酐水平。为了评估PLR与CIN之间的关系，将5719例患者分为CIN组和非CIN组。252例（4.4%）患者发生了造影剂肾病。CIN组患者的PLR显著高于非CIN组（分别为173.8[62.3]和116.2[51.7]；P<0.001）。在逻辑回归分析中，PLR是CIN的独立预测因子（比值比：1.432，95%置信区间：1.205-1.816，P=0.031），同时还有年龄、糖尿病、肌酐、估计肾小球滤过率和中性粒细胞与淋巴细胞比值。总之，较高的PLR是接受pPCI的STEMI患者发生CIN的独立危险因素。
