急性冠状动脉综合征经皮冠状动脉介入治疗后对比剂肾病患者淋巴细胞与单核细胞比值的预测价值
Predictive Value of Lymphocyte-to-monocyte Ratio in Patients with Contrast-induced Nephropathy After Percutaneous Coronary Intervention for Acute Coronary Syndrome.
作者信息
Karauzum Irem, Karauzum Kurtulus, Acar Burak, Hanci Kaan, Bildirici Halil Ibrahim Ulas, Kilic Teoman, Ural Ertan
机构信息
Kocaeli University Faculty of Medicine, Istanbul, Turkey.
Department of Cardiology, Biruni University, Istanbul, Turkey.
出版信息
J Transl Int Med. 2021 Jul 9;9(2):123-130. doi: 10.2478/jtim-2021-0024. eCollection 2021 Jun.
BACKGROUND AND OBJECTIVES
Lymphocyte-to-monocyte ratio (LMR) has emerged as a new indirect marker of inflammation, which is associated with adverse outcomes in cardiovascular diseases. The aim of this study was to evaluate whether admission LMR is associated with contrast-induced nephropathy (CIN) in patients who underwent percutaneous coronary intervention for acute coronary syndrome (ACS).
METHODS
A total of 873 patients were assessed. LMR was calculated via dividing lymphocyte count by monocyte count.
RESULTS
LMR was significantly lower in the with-CIN group. ROC analysis showed that the LMR ratios <2.52 predicted CIN development with sensitivity of 66.3% and specificity of 55.8%. Multivariate analysis showed that eGFR, admission glucose, and LMR were independent predictors of CIN in patients with ACS.
CONCLUSION
LMR is an easily accessible marker and could be used as a predictor of CIN in patients with ACS undergoing percutaneous coronary intervention.
背景与目的
淋巴细胞与单核细胞比值（LMR）已成为一种新的炎症间接标志物，与心血管疾病的不良预后相关。本研究旨在评估急性冠状动脉综合征（ACS）患者经皮冠状动脉介入治疗时入院时的LMR是否与造影剂肾病（CIN）相关。
方法
共评估了873例患者。LMR通过淋巴细胞计数除以单核细胞计数计算得出。
结果
CIN组的LMR显著更低。ROC分析显示，LMR比值<2.52预测CIN发生的敏感性为66.3%，特异性为55.8%。多变量分析显示，估算肾小球滤过率（eGFR）、入院时血糖和LMR是ACS患者CIN的独立预测因素。
结论
LMR是一种易于获取的标志物，可作为接受经皮冠状动脉介入治疗的ACS患者CIN的预测指标。
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