Galvez-Martín Patricia, Martin Jose M, Ruiz Adolfina M, Clares Beatriz
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Granada University, P.O. Box: 180171, Granada, Spain.
Advanced Therapies Area, Bioibérica S.A.U., Barcelona E-08029, Spain.
Curr Pharm Biotechnol. 2017;18(5):365-377. doi: 10.2174/1389201018666170502113252.
The clinical application of cells and the development of new delivery systems have allowed significant advances in the field of cell therapy and encapsulation in recent years. The ability to combine cells and biocompatible matrices in the encapsulation of cells providing long-term delivery has provides new therapeutic alternatives in the development of new therapies.
A structured search of bibliographic databases was carried out to determine the entire methodology related to cell encapsulation with clinical application.
Cell encapsulation provides increased retention time in the target tissue improving its therapeutic efficacy. This technology involves the development of a physical barrier (natural or synthetic matrix surrounded by a semipermeable membrane) to isolate and protect cells from the host's immune system maintaining the microenvironment of embedded cells, their viability and their capacity of differentiation, improving their function in vivo, and reducing side effects associated with the use of immunosuppressive therapy.
The purpose of this review is to discuss the different technologies of cell encapsulation and the different materials utilized from both, natural and synthetic origin, and provide an overview of current therapeutic applications of cell encapsulation, as well as, the perspectives for their clinical application including as a novelty the current application in clinical trials.
近年来，细胞的临床应用以及新型递送系统的开发使细胞治疗和封装领域取得了重大进展。在细胞封装中，将细胞与生物相容性基质相结合以实现长期递送的能力为新疗法的开发提供了新的治疗选择。
对文献数据库进行结构化检索，以确定与具有临床应用的细胞封装相关的完整方法。
细胞封装可延长在靶组织中的保留时间，提高其治疗效果。该技术涉及开发一种物理屏障（由半透膜包围的天然或合成基质），以隔离并保护细胞免受宿主免疫系统的影响，维持嵌入细胞的微环境、其活力及其分化能力，改善其体内功能，并减少与使用免疫抑制疗法相关的副作用。
本综述的目的是讨论细胞封装的不同技术以及天然和合成来源的不同使用材料，概述细胞封装的当前治疗应用，以及其临床应用前景，包括目前在临床试验中的新应用。
