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Commentary: Insulin-Producing Organoids Engineered From Islet and Amniotic Epithelial Cells to Treat Diabetes.评论：由胰岛和羊膜上皮细胞工程化构建的胰岛素分泌类器官用于治疗糖尿病
Front Endocrinol (Lausanne). 2020 Oct 6;11:546114. doi: 10.3389/fendo.2020.546114. eCollection 2020.
2
Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes.由胰岛和羊膜上皮细胞工程化产生的胰岛素分泌类器官用于治疗糖尿病。
Nat Commun. 2019 Oct 3;10(1):4491. doi: 10.1038/s41467-019-12472-3.
3
Bioengineering and vascularization strategies for islet organoids: advancing toward diabetes therapy.胰岛类器官的生物工程和血管化策略：迈向糖尿病治疗的进展。
Metabolism. 2024 Mar;152:155786. doi: 10.1016/j.metabol.2024.155786. Epub 2024 Jan 10.
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Rotational culture and integration with amniotic stem cells reduce porcine islet immunoreactivity in vitro and slow xeno-rejection in a murine model of islet transplantation.旋转培养和与羊膜干细胞的整合减少了体外猪胰岛的免疫反应性，并在胰岛移植的小鼠模型中减缓了异种排斥反应。
Xenotransplantation. 2019 Jul;26(4):e12508. doi: 10.1111/xen.12508. Epub 2019 Apr 8.
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J Nanobiotechnology. 2022 Jun 28;20(1):308. doi: 10.1186/s12951-022-01518-2.
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Islet organoid as a promising model for diabetes.胰岛类器官作为一种有前途的糖尿病模型。
Protein Cell. 2022 Apr;13(4):239-257. doi: 10.1007/s13238-021-00831-0. Epub 2021 Mar 10.
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Cell Transplant. 2011;20(4):523-34. doi: 10.3727/096368910X528111. Epub 2010 Sep 30.
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Reversal of experimental diabetes in mice by transplantation of neo-islets generated from human amnion-derived mesenchymal stromal cells using immuno-isolatory macrocapsules.使用免疫隔离性大囊泡移植人羊膜来源间充质基质细胞生成的新胰岛逆转实验性糖尿病小鼠模型。
Cytotherapy. 2010 Dec;12(8):982-91. doi: 10.3109/14653249.2010.509546. Epub 2010 Aug 31.
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A hydrogel platform for in vitro three dimensional assembly of human stem cell-derived islet cells and endothelial cells.用于人源干细胞来源的胰岛细胞和内皮细胞体外三维组装的水凝胶平台。
Acta Biomater. 2019 Oct 1;97:272-280. doi: 10.1016/j.actbio.2019.08.031. Epub 2019 Aug 22.
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Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr Progenitors.从驻留 Procr 祖细胞长期扩增胰岛类器官。
Cell. 2020 Mar 19;180(6):1198-1211.e19. doi: 10.1016/j.cell.2020.02.048.

引用本文的文献

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Challenges with Cell-based Therapies for Type 1 Diabetes Mellitus.1型糖尿病基于细胞疗法面临的挑战。
Stem Cell Rev Rep. 2023 Apr;19(3):601-624. doi: 10.1007/s12015-022-10482-1. Epub 2022 Nov 25.
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Development of scaffold-free vascularized pancreatic beta-islets in vitro models by the anchoring of cell lines to a bioligand-functionalized gelatine substrate.通过将细胞系锚定到生物配体功能化的明胶基底上，在体外开发无支架血管化的胰腺β-胰岛模型。
J Mater Sci Mater Med. 2022 Apr 11;33(4):37. doi: 10.1007/s10856-022-06658-3.
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Regenerative Engineering: Current Applications and Future Perspectives.再生工程：当前应用与未来展望
Front Surg. 2021 Nov 3;8:731031. doi: 10.3389/fsurg.2021.731031. eCollection 2021.

本文引用的文献

1
Enhanced In Vivo Vascularization of 3D-Printed Cell Encapsulation Device Using Platelet-Rich Plasma and Mesenchymal Stem Cells.利用富含血小板血浆和间充质干细胞增强 3D 打印细胞包封装置的体内血管生成。
Adv Healthc Mater. 2020 Oct;9(19):e2000670. doi: 10.1002/adhm.202000670. Epub 2020 Aug 31.
2
Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes.由胰岛和羊膜上皮细胞工程化产生的胰岛素分泌类器官用于治疗糖尿病。
Nat Commun. 2019 Oct 3;10(1):4491. doi: 10.1038/s41467-019-12472-3.
3
Engineering the vasculature for islet transplantation.工程化血管用于胰岛移植。
Acta Biomater. 2019 Sep 1;95:131-151. doi: 10.1016/j.actbio.2019.05.051. Epub 2019 May 23.
4
Regenerative Medicine and Diabetes: Targeting the Extracellular Matrix Beyond the Stem Cell Approach and Encapsulation Technology.再生医学与糖尿病：超越干细胞方法和封装技术，靶向细胞外基质
Front Endocrinol (Lausanne). 2018 Aug 31;9:445. doi: 10.3389/fendo.2018.00445. eCollection 2018.
5
Islet-Like Structures Generated In Vitro from Adult Human Liver Stem Cells Revert Hyperglycemia in Diabetic SCID Mice.体外由成人肝干细胞生成的胰岛样结构可使糖尿病 SCID 小鼠的高血糖逆转。
Stem Cell Rev Rep. 2019 Feb;15(1):93-111. doi: 10.1007/s12015-018-9845-6.
6
The journey of islet cell transplantation and future development.胰岛细胞移植的历程与未来发展。
Islets. 2018 Mar 4;10(2):80-94. doi: 10.1080/19382014.2018.1428511. Epub 2018 Feb 5.
7
Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases.三维类器官系统移植技术在中枢神经系统疾病未来治疗中的应用
Stem Cells Int. 2017;2017:5682354. doi: 10.1155/2017/5682354. Epub 2017 Aug 20.
8
Encapsulation in Cell Therapy: Methodologies, Materials, and Clinical Applications.细胞治疗中的封装：方法、材料及临床应用
Curr Pharm Biotechnol. 2017;18(5):365-377. doi: 10.2174/1389201018666170502113252.
9
Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo.源自人类多能干细胞的类胰岛类器官在体外和体内的葡萄糖反应性方面具有高效功能。
Sci Rep. 2016 Oct 12;6:35145. doi: 10.1038/srep35145.
10
Engineering islet for improved performance by optimized reaggregation in alginate gel beads.通过在海藻酸盐凝胶珠中进行优化的重新聚集来构建胰岛以提高性能。
Biotechnol Appl Biochem. 2017 May;64(3):400-405. doi: 10.1002/bab.1489. Epub 2017 Apr 26.

Commentary: Insulin-Producing Organoids Engineered From Islet and Amniotic Epithelial Cells to Treat Diabetes.

作者信息

Cobianchi Lorenzo, Moeckli Beat, Croce Stefania

机构信息

Department of General Surgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Department of Clinical, Surgical, Diagnostic & Pediatric Sciences, University of Pavia, Pavia, Italy.

出版信息

Front Endocrinol (Lausanne). 2020 Oct 6;11:546114. doi: 10.3389/fendo.2020.546114. eCollection 2020.

DOI:10.3389/fendo.2020.546114
PMID:33123085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7573304/
Abstract
摘要