Moriello K A, Fehrer-Sawyer S L, Meyer D J, Feder B
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
J Am Vet Med Assoc. 1988 Aug 1;193(3):329-31.
Commercial otic preparations that contained dexamethasone or triamcinolone acetate were applied twice daily to both ears of 2 groups of dogs (n = 8). Marked adrenocortical suppression, reflected by low serum cortisol concentrations, was observed in all dogs. Results of ACTH response tests were blunted after 7 days of treatment. Twenty-one days after treatment, serum cortisol concentrations still were suppressed in all dogs, compared with pretreatment control concentrations. Fourteen days after cessation of otic treatment, 5 of 8 dogs still had inadequate release of cortisol in response to ACTH.
