Jones Daniel P, True Harry D, Patel Jyoti
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford and John Radcliffe Hospital, Oxford OX3 9DU, UK.
Wellcome Trust Centre for Human Genetics, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
Mediators Inflamm. 2017;2017:9746169. doi: 10.1155/2017/9746169. Epub 2017 Mar 30.
Chemokine-induced leukocyte migration into the vessel wall is an early pathological event in the progression of atherosclerosis, the underlying cause of myocardial infarction. The immune-inflammatory response, mediated by both the innate and adaptive immune cells, is involved in the initiation, recruitment, and resolution phases of cardiovascular disease progression. Activation of leukocytes via inflammatory mediators such as chemokines, cytokines, and adhesion molecules is instrumental in these processes. In this review, we highlight leukocyte activation with the main focus being on the mechanisms of chemokine-mediated recruitment in atherosclerosis and the response postmyocardial infarction with key examples from experimental models of cardiovascular inflammation.
趋化因子诱导白细胞迁移至血管壁是动脉粥样硬化进展过程中的早期病理事件，动脉粥样硬化是心肌梗死的根本原因。由先天免疫细胞和适应性免疫细胞介导的免疫炎症反应参与了心血管疾病进展的起始、募集和消退阶段。通过趋化因子、细胞因子和黏附分子等炎症介质激活白细胞在这些过程中起重要作用。在本综述中，我们重点强调白细胞激活，主要关注趋化因子介导的动脉粥样硬化募集机制以及心肌梗死后的反应，并列举心血管炎症实验模型中的关键实例。
