Sfrijan Doinita, Tieranu Ioana, Necula Iulia, Popa Loredana, Balgradean Mihaela
"M.S. Curie" Emergency Children's Hospital, Bucharest, Romania.
Maedica (Bucur). 2016 Mar;11(1):64-67.
There is enough literature data - case reports and case series - regarding the association between nephrotic syndrome (NS) and different neoplasia, but only a few of these data address the specific link between NS and Hodgkin lymphoma. It has been demonstrated that intrinsic renal lesions - glomerular injury - can be found as a complication in these malignancies.
This report presents the case of a 9 year-old child in whom the diagnosis of NS was established two months before the diagnosis of Hodgkin lymphoma. Once chemotherapy was initiated, proteinuria and the clinical manifestations of NS, mainly oedema, disappeared.
Considering that the NS can be a paraneoplastic manifestation of Hodgkin lymphoma, the careful clinical evaluation becomes mandatory in any child with NS and persistent proteinuria despite appropriate treatment protocol. The prognosis of these patients is good, the treatment of Hodgkin disease causing the disappearance of proteinuria.
有足够的文献数据——病例报告和病例系列——涉及肾病综合征（NS）与不同肿瘤之间的关联，但其中只有少数数据涉及NS与霍奇金淋巴瘤之间的具体联系。已经证明，在这些恶性肿瘤中可发现内在性肾脏病变——肾小球损伤——作为一种并发症。
本报告介绍了一名9岁儿童的病例，该儿童在霍奇金淋巴瘤诊断前两个月确诊为NS。一旦开始化疗，蛋白尿和NS的临床表现，主要是水肿，就消失了。
鉴于NS可能是霍奇金淋巴瘤的副肿瘤表现，对于任何患有NS且尽管采用了适当治疗方案仍持续蛋白尿的儿童，必须进行仔细的临床评估。这些患者的预后良好，霍奇金病的治疗导致蛋白尿消失。
