El Fakih Riad, Bajuaifer Yazeed S, Shah Amna Yousaf, Sulaiman Reem, Almohamady Rawan, ELGohary Ghada, Alothaimeen Haya S, Aljurf Mahmoud
Oncology Center, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh, 11471, Saudi Arabia.
Oncology Center, University Medical City, King Saud University, Riyadh, Saudi Arabia.
Ann Hematol. 2024 Apr;103(4):1131-1137. doi: 10.1007/s00277-023-05357-5. Epub 2023 Jul 10.
PNS are uncommon manifestations of cancer. The current literature about these syndromes in the setting of cHL is disintegrated. A systematic literature review of all published literature was conducted. One hundred twenty-eight patients from 115 publications met the inclusion/exclusion criteria. Eight-five patients were of the NS subtype (66.4%). The most frequent clinical presentation of the PNS was CNS manifestation (25.8%). The majority of patients were diagnosed with the cHL and PNS simultaneously (42.2%). In 33.6% of patients, the lymphoma diagnosis preceded the PNS diagnosis. In 16.4% of patients, the PNS diagnosis preceded the lymphoma diagnosis. The presence of PNS antibodies was reported in 35 patients (27.3%). Age older than 18 was associated with higher prevalence of PNS. The CR rate of the lymphoma was 77.3%. The complete resolution rate of the PNS was 54.7%. Relapse of lymphoma was reported in 13 patients, and recurrence of the PNS upon relapse was reported in 10/13 patients.
副肿瘤综合征（PNS）是癌症的罕见表现。目前关于cHL（经典型霍奇金淋巴瘤）背景下这些综合征的文献是零散的。我们对所有已发表的文献进行了系统的文献综述。来自115篇出版物的128例患者符合纳入/排除标准。85例患者为神经综合征（NS）亚型（66.4%）。PNS最常见的临床表现是中枢神经系统表现（25.8%）。大多数患者同时被诊断为cHL和PNS（42.2%）。在33.6%的患者中，淋巴瘤诊断先于PNS诊断。在16.4%的患者中，PNS诊断先于淋巴瘤诊断。35例患者（27.3%）报告存在PNS抗体。年龄大于18岁与PNS的较高患病率相关。淋巴瘤的完全缓解率为77.3%。PNS的完全缓解率为54.7%。13例患者报告了淋巴瘤复发，13例复发患者中有10例报告了PNS复发。
