Yadav Divya, Vargo John, Lopez Rocio, Chahal Prabhleen
Divya Yadav, John Vargo, Prabhleen Chahal, Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, United States.
World J Gastrointest Endosc. 2017 Apr 16;9(4):171-176. doi: 10.4253/wjge.v9.i4.171.
To evaluate the risk of immediate and delayed bleeding following sphincterotomy procedure.
This retrospective cohort study was conducted with all patients who underwent endoscopic sphincterotomy during January 2006 to September 2015 at a tertiary academic center. Patients were grouped according to pre procedural usage of serotonin reuptake inhibitors (SRIs). Both groups were matched for demographic and clinical characteristics. Patients with thrombocytopenia, increased international normalized ratio, or a history of bleeding or coagulation disorders, concurrent use of other antiplatelet/anticoagulants were excluded from the study.
A total of 447 patients were included, of which 219 (45.9%) used SRIs and 228 (54.1%) cases did not. There was no significant difference in acute or delayed bleeding during endoscopic sphincterotomy between the two groups. (8.2% 12.3%, = 0.16).
The use of SRIs was not associated with an increased risk of post-sphincterotomy bleeding. To our best knowledge, this is the first study to explore this association.
评估括约肌切开术后即刻和延迟出血的风险。
本回顾性队列研究纳入了2006年1月至2015年9月在一家三级学术中心接受内镜括约肌切开术的所有患者。根据术前血清素再摄取抑制剂（SRIs）的使用情况对患者进行分组。两组在人口统计学和临床特征方面进行匹配。血小板减少、国际标准化比值升高、有出血或凝血障碍病史、同时使用其他抗血小板/抗凝剂的患者被排除在研究之外。
共纳入447例患者，其中219例（45.9%）使用了SRIs，228例（54.1%）未使用。两组在内镜括约肌切开术期间的急性或延迟出血方面无显著差异。（8.2%对12.3%，P = 0.16）。
使用SRIs与括约肌切开术后出血风险增加无关。据我们所知，这是第一项探讨这种关联的研究。
