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一名2.5岁川崎病男孩的非典型脱屑:病例报告

Atypical desquamation in a 2.5-year-old boy with Kawasaki disease: A case report.

作者信息

Adib Ali, Fazel Ali, Nabavizadeh Seyed Hesamedin, Alyasin Sohaila, Kashef Sara

机构信息

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

MD., Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Electron Physician. 2017 Feb 25;9(2):3764-3767. doi: 10.19082/3764. eCollection 2017 Feb.

DOI:10.19082/3764
PMID:28465804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5410903/
Abstract

Kawasaki disease (KD) is a vasculitis that mostly affects children under 5 years of age. This article presents a 2.5-year-old boy who presented with 6 days of fever, generalized maculopapular rash, bilateral non-exudative conjunctivitis, cracked lips, right cervical lymphadenopathy, erythematous extremities, and perianal desquamation. Laboratory studies showed leukocytosis and sterile pyuria. Because diagnosis of KD was proved, oral acetylsalicylic acid with the anti-inflammatory dose and intravenous immunoglobulin were started for him. On the seventh day of admission time, he developed desquamation and erythema on the site of his right cervical lymphadenopathy as well as periungual scaling. About three weeks after starting the treatment, scaling of the cervical lymphadenopathy and periungual area stopped. Echocardiography was performed for him three times: at the time of diagnosis, four weeks, and 6 months later and revealed normal coronary arteries. We report this sign, desquamation on the site of cervical lymphadenopathy, as a new finding.

摘要

川崎病(KD)是一种主要影响5岁以下儿童的血管炎。本文介绍了一名2.5岁男孩,他出现了6天的发热、全身性斑丘疹、双侧非渗出性结膜炎、嘴唇干裂、右颈部淋巴结病、四肢红斑和肛周脱皮。实验室检查显示白细胞增多和无菌性脓尿。由于KD诊断得到证实,开始给他使用抗炎剂量的口服乙酰水杨酸和静脉注射免疫球蛋白。入院第7天,他右颈部淋巴结病部位出现脱皮和红斑,以及甲周脱屑。开始治疗约三周后,颈部淋巴结病和甲周区域的脱屑停止。对他进行了三次超声心动图检查:诊断时、四周后和6个月后,结果显示冠状动脉正常。我们报告颈部淋巴结病部位的脱皮这一体征为一项新发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/5410903/2313a49a0488/EPJ-09-3764-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/5410903/05e95adec217/EPJ-09-3764-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/5410903/2313a49a0488/EPJ-09-3764-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/5410903/05e95adec217/EPJ-09-3764-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/5410903/2313a49a0488/EPJ-09-3764-g002.jpg

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本文引用的文献

1
Kawasaki disease: an evolving paradigm.川崎病:一个不断发展的范式。
Autoimmun Rev. 2015 Aug;14(8):703-9. doi: 10.1016/j.autrev.2015.04.002. Epub 2015 Apr 13.
2
Diagnosis and management of kawasaki disease.川崎病的诊断与管理
Am Fam Physician. 2015 Mar 15;91(6):365-71.
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Down-regulation of TLR2, 3, 9 and Signaling Mediators, MyD88 and TRIF, Gene Transcript Levels in Patients with Kawasaki Disease Treated with IVIG.静脉注射免疫球蛋白治疗的川崎病患者中TLR2、3、9以及信号转导介质MyD88和TRIF基因转录水平的下调
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Expression of CD11b as an adhesion molecule on neutrophils in children with Kawasaki disease.川崎病患儿中性粒细胞上作为黏附分子的CD11b的表达。
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