Inchingolo Francesco, Vermesan Dino, Inchingolo Alessio D, Malcangi Giuseppina, Santacroce Luigi, Scacco Salvatore, Benagiano Vincenzo, Girolamo Francesco, Cagiano Raffaele, Caprio Monica, Longo Lucia, Abbinante Antonia, Inchingolo Angelo M, Dipalma Gianna, Tarullo Angelo, Tattoli Maria
Acta Biomed. 2017 Apr 28;88(1):45-48. doi: 10.23750/abm.v88i1.5794.
Phenytoin is normally used in epilepsy treatment. One of the side effect affecting a significative part of the treated patients is the gingival overgrowth. It could surely be a correlation between this stimulatory effect and the assessment of phenytoin in wound healing. In fact, some studies of the literature have shown that topical phenytoin promotes healing of traumatic wounds, burns and ulcers by decubitus or stasis (diabetic or venous) and we emphasize, in vitiligo, a particular attention into repigmentation. The related mechanism of action seems to be multifactorial. In the present paper topical phenytoin has been used as wound-healing agent in 19 documented cases of bedsores, divided in treated and placebo group. The used concentration of phenytoin was 5 mg/L dissolved in a water solution of 9 g NaCl /L (0.9% P/V of NaCl). Patches soaked with phenytoin solution were applied over the bedsores along 3 hours every 12 hours. Results showed that phenytoin treated patients healed their wounds significantly before (p<0.001) with respect to controls.
苯妥英通常用于癫痫治疗。影响相当一部分接受治疗患者的副作用之一是牙龈增生。这种刺激作用与苯妥英在伤口愈合中的评估之间肯定存在关联。事实上，文献中的一些研究表明，局部使用苯妥英可促进创伤性伤口、烧伤以及褥疮或淤滞性溃疡（糖尿病性或静脉性）的愈合，并且我们强调，在白癜风中，对色素再生要特别关注。相关的作用机制似乎是多因素的。在本文中，局部使用苯妥英作为伤口愈合剂用于19例记录在案的褥疮病例，分为治疗组和安慰剂组。苯妥英的使用浓度为5mg/L，溶解于9g NaCl/L的水溶液（0.9%w/v的NaCl）中。用苯妥英溶液浸湿的贴片每12小时敷在褥疮上3小时。结果表明，与对照组相比，接受苯妥英治疗的患者伤口愈合明显提前（p<0.001）。
