Meena K, Mohan A V, Sharath B, Somayaji S N, Bairy K L
Department of Pharmacology, Kasturba Medical College, India.
Indian J Exp Biol. 2011 Jan;49(1):56-9.
To evaluate the effect of phenytoin on burn wounds and to compare the effect of the combination of topical phenytoin preparation in dexamethasone treated burn wounds in rats, partial thickness thermal burn wounds were inflicted upon five groups of six rats each. Group I was assigned as control, Group II received the standard silver sulphadiazine, Group III was given topical phenytoin and Group IV received injection dexamethasone, Group V received the combination of the phenytoin and the dexamethasone. The parameters observed were epithelialization period, percentage of wound contraction and histopathological analysis as indicative of the process of healing. Phenytoin group showed significant improvement in burn wound contraction in comparison to standard silver sulphadiazine group, the combination group of topical phenytoin and dexamethasone also showed significant contraction compared to dexamethasone group. The period of epithelialization also decreased significantly in groups II, III and V. In conclusion, phenytoin promotes burn wound healing as evidenced by decrease in period of epithelialization and faster wound contraction.
为评估苯妥英对烧伤创面的影响，并比较局部应用苯妥英制剂联合地塞米松治疗大鼠烧伤创面的效果，将五组每组六只大鼠造成浅Ⅱ度热烧伤创面。第一组作为对照组，第二组给予标准磺胺嘧啶银，第三组给予局部苯妥英，第四组给予地塞米松注射，第五组给予苯妥英和地塞米松联合治疗。观察的参数为上皮化期、创面收缩百分比以及作为愈合过程指标的组织病理学分析。与标准磺胺嘧啶银组相比，苯妥英组在烧伤创面收缩方面有显著改善，局部苯妥英和地塞米松联合组与地塞米松组相比也有显著收缩。第二、三、五组的上皮化期也显著缩短。总之，上皮化期缩短和创面收缩加快证明苯妥英可促进烧伤创面愈合。
