Hooper Claudie, De Souto Barreto Philipe, Payoux Pierre, Salabert Anne Sophie, Guyonnet Sophie, Andrieu Sandrine, Vellas Bruno
Gérontopôle, Department of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France.
UMR1027, Université de Toulouse, UPS, INSERM, Toulouse, France.
J Neurochem. 2017 Aug;142(4):589-596. doi: 10.1111/jnc.14062. Epub 2017 May 29.
Omega-3 (n-3) and 6 (n-6) polyunsaturated fatty acids (PUFAs) have been associated with reduced cognitive decline in observational studies. Hence, we examined the cross-sectional associations between cortical β-amyloid (Aβ) and erythrocyte membrane PUFAs in 61 non-demented elderly individuals reporting subjective memory complaints from the Multidomain Alzheimer Preventive Trial placebo arm. Cortical-to-cerebellar standard uptake value ratios were obtained using [ F] florbetapir positron emission tomography. Fatty acids were measured in erythrocyte membranes by gas chromatography. Associations were explored using adjusted multiple linear regression models and were considered significant at p ≤ 0.005 after correction for multiple testing (10 comparisons). We found no significant associations between cortical Aβ and erythrocyte membrane PUFAs. The associations closest to significance after adjustment were those between Aβ and erythrocyte membrane arachidonic acid (without apolipoprotein E status adjustment: B-coefficient, 0.03; CI, 0.01, 0.05; p = 0.02. Including Apolipoprotein E adjustment: B-coefficient, 0.03; CI, 0.00, 0.06; p = 0.04) and Aβ and erythrocyte membrane linoleic acid (without apolipoprotein E status adjustment: B-coefficient, -0.02; CI, -0.04, 0.00; p = 0.02. Including Apolipoprotein E adjustment: B-coefficient, -0.02; CI, -0.04, 0.00; p = 0.09). Furthermore, the association between Aβ and erythrocyte membrane arachidonic acid seemed to be specific to Apolipoprotein E ε4 non-carriers (B-coefficient 0.03, CI: 0.00, 0.06, p = 0.03, n = 36). In contrast, no association was found between Aβ and erythrocyte membrane linoleic acid in Apolipoprotein E ε4 stratified analysis. Investigating the relationships between Aβ and PUFAs longitudinally would provide further evidence as to whether fatty acids, particularly arachidonic acid and linoleic acid, might modulate cognition through Aβ-dependent mechanisms.
在观察性研究中，ω-3（n-3）和6（n-6）多不饱和脂肪酸（PUFAs）与认知能力下降减缓有关。因此，我们在61名来自多领域阿尔茨海默病预防试验安慰剂组、自述有主观记忆问题的非痴呆老年人中，研究了皮质β-淀粉样蛋白（Aβ）与红细胞膜PUFAs之间的横断面关联。使用[F]氟比他班正电子发射断层扫描获得皮质与小脑的标准摄取值比率。通过气相色谱法测量红细胞膜中的脂肪酸。使用校正后的多元线性回归模型探索关联，并在多重检验校正（10次比较）后，将p≤0.005视为具有显著意义。我们发现皮质Aβ与红细胞膜PUFAs之间无显著关联。校正后最接近显著意义的关联是Aβ与红细胞膜花生四烯酸之间的关联（未调整载脂蛋白E状态：B系数，0.03；可信区间，0.01，0.05；p = 0.02。纳入载脂蛋白E调整：B系数，0.03；可信区间，0.00，0.06；p = 0.04）以及Aβ与红细胞膜亚油酸之间的关联（未调整载脂蛋白E状态：B系数，-0.02；可信区间，-0.04，0.00；p = 0.02。纳入载脂蛋白E调整：B系数，-0.02；可信区间，-0.04，0.00；p = 0.09）。此外，Aβ与红细胞膜花生四烯酸之间的关联似乎对非载脂蛋白E ε4携带者具有特异性（B系数0.03，可信区间：0.00，0.06，p = 0.03，n = 36）。相反地，在载脂蛋白E ε4分层分析中，未发现Aβ与红细胞膜亚油酸之间存在关联。纵向研究Aβ与PUFAs之间的关系，将为脂肪酸，尤其是花生四烯酸和亚油酸，是否可能通过Aβ依赖机制调节认知提供进一步证据。
